Tonifying kidney and activating blood therapy for the treatment of diabetic erectile dysfunction: A systematic review and meta-analysis.
- Author:
Mao-Ke CHEN
1
;
Ke-Cheng LI
1
;
Jun-Long FENG
1
;
Xiang-Fa LIN
1
;
Wen-Xuan DONG
1
;
Zi-Xiang GAO
1
;
Hua-Nan ZHANG
1
;
Hui CHEN
1
;
Ji-Sheng WANG
1
;
Bin WANG
1
Author Information
1. Department of Andrology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.
- Publication Type:English Abstract
- Keywords:
Tonifying kidney and activating blood therapy;
diabetic mellitus erectile dysfunction;
meta-analysis
- MeSH:
Humans;
Male;
Erectile Dysfunction/therapy*;
Randomized Controlled Trials as Topic;
Kidney;
Medicine, Chinese Traditional;
Diabetes Complications/therapy*
- From:
National Journal of Andrology
2025;31(9):832-840
- CountryChina
- Language:Chinese
-
Abstract:
Objective： To systematically evaluate the clinical efficacy and safety of Tonifying kidney and activating blood therapy for the treatment of diabetic mellitus erectile dysfunction. Methods： China National Knowledge Infrastructure(CNKI), Wanfang Data, VIP, Chinese Biomedical Database(CBM), PubMed, Cochrane Library, Embase and Web of Science were searched from inception until October 20th of 2024，for randomized controlled trials of Tonifying kidney and activating blood therapy for the treatment of diabetic erectile dysfunction. Literature screening, quality evaluation, and data extraction were carried out in accordance with relevant standards. The software of RevMan5.4 was used for the analysis of publication bias. And meta-analysis was conducted to assess the impact of this therapy on IIEF-5, total effective rate, adverse reactions. The evidence levels according to the analysis results were evaluated. Results: Totally 19 RCTs were included, involving 1 612 patients. The result of meta-analysis indicated that Tonifying kidney and activating blood therapy had advantages on the improvement of IIEF-5 scores (MD=3.59，95%CI［2.14，5.03］，P<0.01)，total effective rate (OR=4.30，95%CI［3.29，5.32］，P<0.000 01）. However, there was no statistically significant difference in the incidence of adverse reactions(OR=0.98，95%CI［0.48，2.01］，P=0.96) between the two groups. Conclusions： Tonifying kidney and activating blood therapy can improve the clinical efficacy and IIEF-5 score for the patients with diabetic erectile dysfunction. But considering the limited quantity of included studies, more high-quality studies still be needed to validate the therapeutic effect.
