Causal relationship between insomnia and erectile dysfunction based on heart-kidney intersection theory:A two-sample Mendelian randomization study
10.13263/j.cnki.nja.2025.07.003
- VernacularTitle:基于"心肾相交"理论探讨失眠与勃起功能障碍的因果关系:应用两样本孟德尔随机化研究
- Author:
Ze-rui QIU
1
;
Guang-yang OU
;
Heng-jie LIU
;
Wen-tao MA
;
Man-jie HUANG
;
Neng WANG
;
Jun ZHOU
;
Qing ZHOU
Author Information
1. 湖南中医药大学第一中医临床学院,湖南长沙 410007
- Publication Type:Journal Article
- Keywords:
erection dysfunction;
insomnia;
Mendelian randomization;
heart-kidney interaction
- From:
National Journal of Andrology
2025;31(7):597-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Previous studies have shown that insomnia is closely related to erectile dysfunction(ED).However,the causal relationship between them is still unclear.Mendelian randomization(MR)provides a new method for studying the relationship between the two,and the theory of heart-kidney interaction in TCM provides a new idea for exploring the causal relationship between them.Methods:Based on the statistical data collected by genome-wide association studies(GWAS),the causal relationship be-tween insomnia and ED was discussed by MR.Inverse variance weighted(IVW)is the main analysis method,and weighted median(WME),simple mode(SM),weighted mode(WM)and MR Egger method were the supplementary analysis to evaluate the causal effect.MR-Egger intercept test,Cochran Q test and leave-one-out method were used in sensitivity analysis to verify the reliability of MR results.Results:Thirty-nine SNPs significantly related to insomnia were finally included for MR analysis.The results of IVW method in MR analysis showed that insomnia had a significant causal relationship with the increased risk of ED(OR=3.111,95％CI=1.566-6.181,P=1.193 × 10-3).The results obtained by MR-Egger method,WME method,WM method and SM method were consistent with IVW method in the direction of effect.The sensitivity results suggested that the results of this study were robust.Conclusion:Our study reveals the causal relationship between insomnia and ED,which provides a new basis for future clinical practice and prevention and treatment of ED.
