Efficacy and safety of stem cell therapy for erectile dysfunction:A systematic review and Meta-analysis
10.13263/j.cnki.nja.2025.06.008
- VernacularTitle:干细胞治疗勃起功能障碍的有效性及安全性:一项系统综述和Meta分析
- Author:
Ming-hui HUANG
1
;
Jia-yu ZHAO
;
Xue-jun SHANG
;
Yong-jun LIU
Author Information
1. 中国药科大学继续教育学院,江苏南京 211198
- Publication Type:Journal Article
- Keywords:
erectile dysfunction;
stem cell therapy;
Meta-analysis
- From:
National Journal of Andrology
2025;31(6):535-546
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the safety,efficacy and potential impact of stem cell therapy(SCT)in improving erectile dys-function(ED).Methods:A comprehensive search strategy was used to search the literatures on safety and efficacy evaluation of stem cell(SC)in the treatment of ED by human clinical trials from PubMed,Embase and Web of science databases with a search time frame from database creation to July 4,2024.The exclusion criteria were as follows:reviews,conference abstracts,animal experi-ments,and duplicate sample literature.Results:The study initially screened 1 773 papers,and 17 were included in the final analy-sis.These studies involved a total of 269 ED patients,and a variety of sources of stem cells had been used in the treatment of ED,in-cluding adipose-derived stem cells,bone marrow-derived stem cells,placental stroma-derived stem cells,umbilical cord-derived stem cells,dental pulp-derived stem cells,and oral mucosa-derived stem cells.All studies were conducted by injecting stem cells into the cavernous body of the penis,but there is no fixed standard for the amount of injection,injection site and number of injections.The op-timal treatment mode was still being explored.Patients' International Index of Erectile Function(IIEF)scores and Erection Hardness Score(EHS),peak systolic velocity(PSV),and end diastolic velocity(EDV)improved after treatment.But some studies showed that the efficacy of the treatment diminished with increasing time.No serious adverse effects were reported in any of the studies and none of the adverse effects persisted for a long period of time.The most common adverse effects included injection site reactions,and SCT showed a good safety and tolerability profile.Conclusion:SCT has the potential to be a promising and innovative regenerative therapy option for ED patients.In the future,with the advancement of stem cell technology,larger randomized controlled studies should continue to be conducted to explore standardized treatments,so as to further evaluate the long-term efficacy and safety of SCT for ED.
