Effect of Y chromosome microdeletion on pregnancy outcome of intracytoplasmic sperm injection
10.13263/j.cnki.nja.2025.06.003
- VernacularTitle:Y染色体AZFc微缺失患者行卵细胞胞质内单精子注射对妊娠结局的影响
- Author:
Qi-min TIAN
1
;
Xiao-dong ZHAO
;
Ting-ting JI
;
Xiao-ling MA
Author Information
1. 兰州大学第一临床医学院,甘肃兰州 730000;甘肃省生殖疾病临床医学研究中心,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
intracytoplasmic sperm injection;
Y chromosome microdeletion;
pregnancy outcome
- From:
National Journal of Andrology
2025;31(6):499-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of Y chromosome AZFc microdeletion on pregnancy outcome of intracytoplasmic sperm injection(ICSI).Methods:From 2016 to 2023,6 765 cases of oligozoospermia in our hospital were selected as the research objects.The results of Y chromosome microdeletion test were retrospectively analyzed.According to the inclusion exclusion criteria and the principle of propensity distribution 1∶2,180 patients were included in the study.Sixty patients with Y chromosome AZFc microde-letion and ICSI assisted pregnancy were enrolled into the experimental group.The other 120 patients without Y chromosome microde-letion and ICSI assisted pregnancy were included in the control group.Baseline characteristics,five male sex hormones,laboratory em-bryo culture and pregnancy outcomes were compared between the two groups.Results:There was no significant difference in male age,female age,infertility years,gravidity and parity between the two groups(P＞0.05).There was no significant difference in the five sex hormones of men(P＞0.05).Except for transplantable embryos(P＜0.05),there was no significant difference in other indi-cators in the process of embryo culture.There was no difference in pregnancy outcome indicators between the two groups except for the preterm birth rate(P＜0.05).Conclusion:ICSI assisted pregnancy with Y chromosome AZFc microdeletion has no significant effect on pregnancy outcome.And close follow-up of offspring is required.
