Research progress on the mechanisms of male reproductive function damage by bisphenol A and traditional Chinese medicine intervention.
- Author:
Nian-Wen HUANG
1
;
Zun-Guang BAI
1
;
Zhi-Ming HONG
2
;
Huan-Zhou BI
3
Author Information
1. Department of Urology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, Guangdong 510120, China.
2. Department of Andrology, Shenzhen Hospital of Traditional Chinese Medicine Shenzhen, Guangdong 518033, China.
3. Department of Urology, Shenzhen Hospital of Beijing University of Chinese Medicine, Shenzhen, Guangdong 518172, China.
- Publication Type:English Abstract
- Keywords:
bisphenol A;
reproductive toxicity;
traditional Chinese medicine;
mechanism of action;
male infertility
- MeSH:
Humans;
Benzhydryl Compounds/adverse effects*;
Male;
Phenols/adverse effects*;
Medicine, Chinese Traditional;
Infertility, Male/chemically induced*;
Testis/drug effects*;
Drugs, Chinese Herbal/therapeutic use*;
Bisphenol A Compounds
- From:
National Journal of Andrology
2025;31(5):457-461
- CountryChina
- Language:Chinese
-
Abstract:
Bisphenol A (BPA) is a kind of exogenous chemicals presenting in the human living environment widely which affects the action of endocrine hormones in the human body. Numerous studies have shown that BPA has reproductive toxicity in the spermatogenic function damage of the testes through a variety of mechanisms such as interfering with endocrine function, inducing oxidative stress, promoting spermatogonial cell apoptosis, destroying the integrity of the blood-testis barrier, and regulating epigenetic inheritance, thereby destroying male fertility. Relevant studies have shown that TCM can improve male fertility by reversing BPA-induced reproductive damage through multi-component, multi-target and multi-mechanisms. However, there is no systematic review on the mechanism of TCM to reduce the reproductive toxicity of BPA. Based on the existing studies, this article will systematically introduce the mechanisms of BPA-induced reproductive impairment in men and the progress of TCM interventions, with a view to providing reference targets and research directions for the development of new Chinese medicines.
