Association of angiotensin Ⅱ type 1 receptor autoantibody and sperm motility in human semen.
- Author:
Dao-Qin TU
1
;
Yu-Huan YANG
1
;
Gui-Fang YANG
2
;
Yi-Nan ZHANG
2
;
Yao CHEN
2
;
Xue-Ming LI
2
;
Yu-Hui SHI
3
;
Xiao-Li YANG
2
;
Feng WANG
1
Author Information
1. Department of Physiology and Pathophysiology， School of Basic Medical Sciences， Shanxi Medical University， Taiyuan， Shanxi 030606， China.
2. Assisted Reproduction Center， Taiyuan Central Hospital Affiliated Shanxi Medical University， Taiyuan， Shanxi 030032， China.
3. Department of Fenyang College, Shanxi Medical University, Taiyuan， Shanxi 032299， China.
- Publication Type:Journal Article
- Keywords:
angiotensin Ⅱ type 1 receptor autoantibody;
sperm quality;
sperm motility;
semen
- MeSH:
Male;
Humans;
Autoantibodies;
Sperm Motility;
Semen;
Retrospective Studies;
Receptor, Angiotensin, Type 1/immunology*;
Animals;
Rats;
Angiotensin II;
Adult;
Sperm Count;
Semen Analysis;
Receptor, Angiotensin, Type 2/immunology*
- From:
National Journal of Andrology
2025;31(5):387-394
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) and semen parameters. Methods： The semen samples of 820 male patients who were treated in the Reproductive Medicine Center of Taiyuan Central Hospital from August 2022 to August 2023 were retrospectively analyzed. The levels of AT1-AA and Ang Ⅱ of semen were detected by ELISA, and the function of AT1-AA was detected by cardiomyocyte beating assay in suckling rats. The patients were divided into low group, median group and high group according to the OD values of AT1-AA. The differences in general data and semen parameters between different groups were analyzed. And the correlation between AT1-AA level and semen parameters in semen of all study subjects was analyzed by the method of Spearman analysis. And the relationships between AT1-AA OD value, Ang Ⅱ level and semen parameters in the AT1-AA high value group were analyzed as well.
RESULTS:AT1-AA was present in semen with good function. There was no significant difference in the general data of patients in different AT1-AA levels (P>0.05). In the comparison of semen parameters among the groups with different levels of AT1-AA, there were differences in sperm concentration, PR concentration, NP％, and ALH among the three groups (P<0.05). And AT1-AA OD value was positively correlated with total sperm count, sperm concentration, PR concentration, and NP％, and negatively correlated with semen volume (P<0.05). In the AT1-AA high value group, the OD value of AT1-AA in semen was negatively correlated with inactive sperm, and positively correlated with total motility (［PR+NP］％), curve rate, mean path rate, and ALH. However, there was no correlation between the level of Ang Ⅱ in semen and semen parameters (P>0.05).
CONCLUSION:The presence of AT1-AA in semen may be associated with the promotion of sperm motility.
