Impact and action mechanisms of obesity on male reproductive function: An update.
- Author:
Ran WEI
1
;
Zhe-Tao LANG
1
;
Er-Hui WANG
1
Author Information
1. Department of Nursing, School of Medicine, Shaoxing College of Arts and Sciences, Shaoxing, Zhejiang 312000, China.
- Publication Type:English Abstract
- Keywords:
obesity;
male reproduction;
testis;
testosterone;
sperm
- MeSH:
Male;
Obesity/physiopathology*;
Humans;
Animals;
Hypothalamo-Hypophyseal System;
Testis/physiopathology*;
Oxidative Stress;
Infertility, Male/etiology*;
Reproduction;
Blood-Testis Barrier
- From:
National Journal of Andrology
2025;31(4):357-362
- CountryChina
- Language:Chinese
-
Abstract:
The adverse effects of obesity on male reproductive function are mainly manifested as the abnormal development of the reproductive system, decrease of testosterone level, decline of sperm quality, and impact on the health of offspring, while its regulatory mechanism is far from being clarified. This paper expounds the influence of obesity on the male reproductive system in the aspects of population epidemiology and animal experiments, presents an overview on the action mechanisms of obesity from the perspectives of the hypothalamus-pituitary-testis axis, blood-testis barrier, inflammatory reaction, oxidative stress, testicular germ cell apoptosis, and impact of paternal obesity on the health of offspring, aiming to shed some light on the clinical treatment and prevention of obesity-related male reproductive dysfunction.
