Influencing factors of positive surgical margins after radical resection of prostate cancer.
- Author:
Chang-Jie SHI
1
;
Zhi-Jian REN
1
;
Ying ZHANG
1
;
Ding WU
1
;
Bo FANG
1
;
Xiu-Quan SHI
1
;
Wen CHENG
1
;
Dian FU
1
;
Xiao-Feng XU
1
Author Information
1. Department of Urology, General Hospital of Eastern Theater Command, Nanjing, Jiangsu 210002, China.
- Publication Type:Journal Article
- Keywords:
radical resection of prostate cancer;
Gleason score;
prostate-specific antigen;
pathological stage;
incisal positive
- MeSH:
Margins of Excision;
Prostatic Neoplasms/surgery*;
Prostatectomy/statistics & numerical data*;
Prostate/surgery*;
Retrospective Studies;
Neoplasm Grading/statistics & numerical data*;
Prostate-Specific Antigen/blood*;
Neoplasm Staging/statistics & numerical data*;
Postoperative Period;
Risk Factors;
Humans;
Male
- From:
National Journal of Andrology
2025;31(4):328-332
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the influencing factors of pathological positive surgical margins (PSM) after radical resection of prostate cancer.
METHODS:The clinical data of 407 patients who underwent radical resection of prostate cancer in our hospital from 2011 to 2020 were retrospectively analyzed. And the patients were divided into two groups according to postoperative pathological results. Single factor analysis was used to evaluate the differences in postoperative Gleason score, preoperative total prostate-specific antigen (tPSA), preoperative serum free prostate-specific antigen to preoperative tPSA ratio (fPSA/ tPSA), clinical stage, postoperative pathological stage, operation method, age, body mass index (BMI), diameter and volume of prostate tumor. Multivariate logistic regression was used to determine the independent risk factor of PSM.
RESULTS:Among 407 patients with prostate cancer, 179 cases (43.98%) were positive. Univariate analysis showed that there were significant differences in postoperative Gleason score, preoperative tPSA, clinical stage and postoperative pathological stage between the two groups (P<0.05). And Gleason score, preoperative tPSA and pathologic stage were independent risk factors for PSM.
CONCLUSION:There are relationships between PSM and postoperative Gleason score, tPSA, clinical T stage, postoperative pathologic pT stage. Among them, postoperative Gleason score (Gleason=7 points, Gleason≥8 points), preoperative total prostate-specific antigen (tPSA > 20 μg/L), and postoperative pathologic pT stage (pT3a, pT3b) were independent risk factors for positive pathological margins of prostate cancer.
