Exploring the causal relationship between leukocyte telomere length and prostatitis,orchitis,and epididymitis based on a two-sample Mendelian randomization
10.13263/j.cnki.nja.2025.04.003
- VernacularTitle:基于两样本孟德尔随机化探讨白细胞端粒长度与前列腺炎、睾丸炎和附睾炎的因果关系
- Author:
Dan-yang LI
1
;
Shun YU
;
Bo-hui YANG
;
Jun-bao ZHANG
;
Guo-chen YIN
;
Lin-na WU
;
Qin-zuo DONG
;
Jin-long XU
;
Shu-ping NING
;
Rong ZHAO
Author Information
1. 云南中医药大学第二临床医学院,云南 昆明 650500
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
prostatitis;
orchitis;
epididymitis;
leukocyte telomere length
- From:
National Journal of Andrology
2025;31(4):306-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the genetic causal relationship of leukocyte telomere length(LTL)with prostatitis,orchi-tis and epididymitis by two-sample Mendelian randomization(MR).Methods:Using LTL as the exposure factor and prostatitis,or-chitis and epididymitis as outcome factors,we mined the Database of Genome-Wide Association Studies(GWAS).Then,we analyzed the causal relationship of LTL with prostatitis,orchitis and epididymitis by Mendelian randomization using inverse variance weighting(IVW)as the main method and weighted median and MR-Egger regression as auxiliary methods,determined the horizontal multiplicity by MR-Egger intercept test,and conducted sensitivity analysis using the leaving-one-out method.Results:A total of 121 related sin-gle nucleotide polymorphisms(SNPs)were identified in this study.IVW showed LTL to be a risk factor for prostatitis(OR=1.383,95％CI:1.044-1.832,P=0.024),and for orchitis and epididymitis as well(OR=1.770,95％CI:1.275-2.456,P=0.000 6).Conclusion:Genetic evidence from Mendelian randomized analysis indicates that shortening of LTL reduces the risk of prostatitis,orchitis and epididymitis.
