Exploring the causal relationship between leukocyte telomere length and prostatitis, orchitis, and epididymitis based on a two-sample Mendelian randomization.
- Author:
Dan-Yang LI
1
;
Shun YU
1
;
Bo-Hui YANG
1
;
Jun-Bao ZHANG
1
;
Guo-Chen YIN
1
;
Lin-Na WU
2
;
Qin-Zuo DONG
2
;
Jin-Long XU
2
;
Shu-Ping NING
3
;
Rong ZHAO
2
Author Information
1. Second School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
2. First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming, Yunnan 650500, China.
3. Department of Acupuncture Binchuan Hospital of Traditional Chinese Medicine, Dali, Yunnan 671600, China.
- Publication Type:Journal Article
- Keywords:
Mendelian randomization;
prostatitis;
orchitis;
epididymitis;
leukocyte telomere length
- MeSH:
Humans;
Male;
Mendelian Randomization Analysis;
Epididymitis/genetics*;
Prostatitis/genetics*;
Polymorphism, Single Nucleotide;
Leukocytes;
Orchitis/genetics*;
Genome-Wide Association Study;
Telomere;
Risk Factors
- From:
National Journal of Andrology
2025;31(4):306-312
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the genetic causal relationship of leukocyte telomere length (LTL) with prostatitis, orchitis and epididymitis by two-sample Mendelian randomization (MR).
METHODS:Using LTL as the exposure factor and prostatitis, orchitis and epididymitis as outcome factors, we mined the Database of Genome-Wide Association Studies (GWAS). Then, we analyzed the causal relationship of LTL with prostatitis, orchitis and epididymitis by Mendelian randomization using inverse variance weighting (IVW) as the main method and weighted median and MR-Egger regression as auxiliary methods, determined the horizontal multiplicity by MR-Egger intercept test, and conducted sensitivity analysis using the leaving-one-out method.
RESULTS:A total of 121 related single nucleotide polymorphisms (SNPs) were identified in this study. IVW showed LTL to be a risk factor for prostatitis (OR = 1.383, 95% CI: 1.044－1.832, P = 0.024), and for orchitis and epididymitis as well (OR = 1.770, 95% CI: 1.275－2.456, P = 0.000 6).
CONCLUSION:Genetic evidence from Mendelian randomized analysis indicates that shortening of LTL reduces the risk of prostatitis, orchitis and epididymitis.
