Brain function and connection in patients with refractory overactive bladder and healthy population: Analysis based on resting-state functional MRI.
- Author:
Yu-Wei ZHANG
1
;
Si-Yi FU
2
;
Yu-Min LIU
3
;
Hui-Hui SONG
3
;
Peng JIANG
4
;
Jia XU
5
;
Bin HU
5
Author Information
1. Department of Urology, Jiangnan University Medical Center, Wuxi, Jiangsu 214002, China.
2. Medical School of Jiangnan University, Wuxi, Jiangsu 214122, China.
3. Department of Neurology, Jiangnan University Medical Center, Wuxi, Jiangsu 214002, China.
4. Center of Physical Examination, Jiangnan University Medical Center, Wuxi, Jiangsu 214002, China.
5. Clinical Laboratory, Jiangnan University Medical Center, Wuxi, Jiangsu 214002, China.
- Publication Type:Journal Article
- Keywords:
refractory overactive bladder;
resting-state functional magnetic resonance imaging;
brain functional network;
neurogenic theory;
brain-bladder axis
- MeSH:
Humans;
Urinary Bladder, Overactive/physiopathology*;
Magnetic Resonance Imaging;
Brain/physiopathology*;
Female;
Male;
Adult;
Surveys and Questionnaires;
Case-Control Studies;
Middle Aged;
Rest;
Brain Mapping
- From:
National Journal of Andrology
2025;31(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the characteristics of central nervous system regulation in patients with refractory overactive bladder (rOAB) using resting-state functional magnetic resonance imaging (rs-fMRI), and to analyze the differences in brain function and connection between the patients and healthy population.
METHODS:From May 1 to November 30, 2024, we performed rs-fMRI for 47 rOAB patients and another 47 matched healthy controls, documented relevant clinical data from all the participants and obtained their Overactive Bladder Symptom Scores (OABSS) and Overactive Bladder Questionnaire (OAB-Q) scores. Based on rs-fMRI, we compared the results of Independent Component Analysis (ICA), amplitude of low-frequency fluctuations (ALFF), fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo) and degree centrality (DC) between the rOAB patients and healthy controls.
RESULTS:The rOAB patients, in comparison with the healthy controls, showed dramatically higher daytime urination frequency (11.64 ± 3.85) vs (5.76 ± 0.91), nighttime urination frequency (3.72 ± 1.64) vs (0.31 ± 0.47), OABSS (8.22 ± 2.21) vs (0.64±0.78), OAB-Q1 score (20.85 ± 5.28) vs (6.78 ± 1.04), and OAB-Q2 score (45.04 ± 12.11) vs (14.51 ± 1.66) (all P<0.01). No statistically significant differences were observed in the results of ICA and ALFF between the right superior frontal and right middle frontal regions in the rOAB patients (P>0.05), but fALFF, ReHo and DC were significantly decreased in the patients compared with those in the healthy controls (P<0.01).
CONCLUSION:Compared with healthy population, the functions and connection of the frontal superior right and frontal middle right brain regions in rOAB patients are significantly down-regulated, which may serve as new therapeutic targets.
