Impacts of advanced male age on sperm DNA methylation and subsequent development of embryos and offspring
10.13263/j.cnki.nja.2025.02.011
- VernacularTitle:高龄对男性精子DNA甲基化及后续对胚胎和子代发育的影响
- Author:
Wen LIU
1
;
Ge FANG
1
;
Xiao LI
1
;
Shao-ming LU
1
Author Information
1. 山东大学妇儿与生殖健康研究院/山东大学附属生殖医院;山东大学生殖医学与子代健康全国重点实验室;山东大学国家辅助生殖与优生工程技术研究中心;山东大学生殖内分泌教育部重点实验室;山东省生殖健康技术创新中心;山东省生殖健康临床医学研究中心;山东省生殖生育研究与出生缺陷防控重点实验室(筹);中国医学科学院配子发生与辅助生殖子代健康研究创新单元(2021RU001),山东济南 250012
- Publication Type:Journal Article
- Keywords:
DNA methylation;
advanced age;
male infertility;
reproduction outcome
- From:
National Journal of Andrology
2025;31(2):172-176
- CountryChina
- Language:Chinese
-
Abstract:
Male factors contribute to infertility at roughly the same rate as female factors,and sperm DNA methylation in ad-vanced-aged males directly affects semen parameters and significantly reduces fertility and increases the miscarriage rate of spouses.Many adverse outcomes of reproductive health are associated with advanced reproductive age of men,and few studies are reported on the influence of paternal age on the health of the offspring.The role of advanced age in human sperm DNA methylation variation and mechanism of its subsequent influence on the offspring health remain unclear.Attention should be paid to the influence of reproductive age on pregnancy outcomes in this population.This reviews focuses on the impacts of advanced male age on sperm DNA methylation and consequently on reproductive outcomes and the offspring,with elucidation of its underlying mechanisms,aiming to provide some more useful evidence for solving related clinical problems.
