Impacts of advanced male age on sperm DNA methylation and subsequent development of embryos and offspring.
- Author:
Wen LIU
1
,
2
,
3
,
4
,
5
,
6
,
7
,
8
;
Ge FANG
1
,
2
,
3
,
4
,
5
,
6
,
7
,
8
;
Xiao LI
1
,
2
,
3
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4
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5
,
6
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7
,
8
;
Shao-Ming LU
1
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2
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3
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4
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5
,
6
,
7
,
8
Author Information
1. Shandong University Research Institute of Women, Children and Reproductive Health / Reproduction Hospital Affiliated to Shandong University,
2. National Key Laboratory of Shandong University for Reproductive Medicine and Offspring Health,
3. National Research Center of Shandong University for Assisted Reproductive Technology and Eugenic Engineering,
4. Shandong University Key Laboratory of the Education Ministry for Reproductive Endocrinology,
5. Shandong Province Technology Innovation Center for Reproductive Health,
6. Shandong Province Clinical Medical Research Center for Reproductive Health,
7. Key Laboratory of Shandong Province for Reproductive Research and Birth Defect Prevention (Under Construction),
8. Innovation Unit of the Chinese Academy of Medical Sciences for Gametogenesis and ART-Offspring Health (2021RU001), Jinan, Shandong 250012, China.
- Publication Type:English Abstract
- Keywords:
DNA methylation;
advanced age;
male infertility;
reproduction outcome
- MeSH:
Humans;
DNA Methylation;
Male;
Spermatozoa/metabolism*;
Female;
Pregnancy;
Paternal Age;
Pregnancy Outcome;
Embryonic Development
- From:
National Journal of Andrology
2025;31(2):172-176
- CountryChina
- Language:Chinese
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Abstract:
Male factors contribute to infertility at roughly the same rate as female factors, and sperm DNA methylation in advanced-aged males directly affects semen parameters and significantly reduces fertility and increases the miscarriage rate of spouses. Many adverse outcomes of reproductive health are associated with advanced reproductive age of men, and few studies are reported on the influence of paternal age on the health of the offspring. The role of advanced age in human sperm DNA methylation variation and mechanism of its subsequent influence on the offspring health remain unclear. Attention should be paid to the influence of reproductive age on pregnancy outcomes in this population. This reviews focuses on the impacts of advanced male age on sperm DNA methylation and consequently on reproductive outcomes and the offspring, with elucidation of its underlying mechanisms, aiming to provide some more useful evidence for solving related clinical problems.
