Research Progress on the Potential Mechanisms of Hyper-progressive Disease
in Immune Checkpoint Blockade Therapy of Solid Tumors.
10.3779/j.issn.1009-3419.2025.106.27
- Author:
Tingting LIU
1
;
Kai ZHU
2
;
Jiong DENG
1
Author Information
1. Medical Research Center, Binzhou Medical University Hospital, Binzhou 256600, China.
2. Department of Nuclear Medicine, Binzhou Medical University Hospital, Binzhou 256600, China.
- Publication Type:English Abstract
- Keywords:
Hyper-progressive disease;
Immune checkpoint blockade;
Immune escape;
Metabolic reprogramming;
Tumor microenvironment
- MeSH:
Humans;
Immune Checkpoint Inhibitors/adverse effects*;
Neoplasms/therapy*;
Disease Progression;
Animals;
Immunotherapy
- From:
Chinese Journal of Lung Cancer
2025;28(9):700-709
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint blockade (ICB) therapy has demonstrated significant efficacy in the treatment of various cancers. However, a subset of patients develops hyper-progressive disease (HPD) following ICB, which is characterized by accelerated tumor growth and poor clinical outcomes. This review outlines the clinical features, potential mechanisms, and possible intervention strategies of HPD, with the aim of informing clinical practice and providing relevant recommendations.
.
