Application and Progress of Organoid-on-a-chip Platforms
in Lung Cancer Diagnosis and Therapy.
10.3779/j.issn.1009-3419.2025.101.16
- Author:
Wuyang YUN
1
;
Xiaoyun ZHANG
2
;
Li XIAO
1
Author Information
1. College of Pulmonary and Critical Care Medicine, Beijing Key Laboratory of Organ Transplantation and Immunology Regulatory, The 8th Medical Centre of Chinese PLA General Hospital, Beijing 100091, China.
2. Hebei North University, Zhangjiakou 075000, China.
- Publication Type:English Abstract
- Keywords:
Antitumor drug screening assays;
Immunotherapy;
Lung neoplasms;
Organoid;
Organoid-on-a-chip
- MeSH:
Humans;
Lung Neoplasms/drug therapy*;
Organoids/drug effects*;
Lab-On-A-Chip Devices;
Animals;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2025;28(9):689-699
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer remains one of the most prevalent and lethal malignancies worldwide. The advancement of its precise diagnosis and therapeutic development urgently requires in vitro models that can highly recapitulate the pathophysiological characteristics of human tissues. Organ-on-a-chip has emerged as a novel technological platform that integrates microfluidic engineering, biomaterials, and other engineering strategies with organoid culture. This platform enables precise control over the cellular microenvironment, thereby closely mimicking the three-dimensional structure and physiological functions of human organs in vitro. Organ-on-a-chip systems demonstrate significant advantages in cancer research, developmental biology, and disease modeling, as they not only preserve the heterogeneity and pathological features of patient samples but also support co-culture of various cell types to reconstruct the tumor microenvironment (TME). However, standardized construction methods and integrated analytical strategies for this technology in lung cancer research remain to be further refined. This review systematically elaborates on the key technical principles of organ-on-a-chip and its recent advances in lung cancer modeling, drug screening, and immunotherapy research. It aims to provide a theoretical foundation and technical perspective for promoting the deeper application of organ-on-a-chip in precision medicine and translational research for lung cancer.
.
