Cytomegalovirus Gastritis Induced by Immune Checkpoint Inhibitors Treatment
in Lung Adenocarcinoma: A Case Report.
10.3779/j.issn.1009-3419.2025.102.31
- Author:
Xiaoyan SI
1
;
Bei TAN
2
;
Xin CHENG
3
;
Mengzhao WANG
1
;
Xiaotong ZHANG
1
;
Li ZHANG
1
Author Information
1. Department of Pulmonary and Critical Care Medicine,
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing 100730, China.
2. Department of Gastroenterology,
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing 100730, China.
3. Department of Nuclear Medicine,
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College,
Beijing 100730, China.
- Publication Type:English Abstract
- Keywords:
Case report;
Cytomegalovirus gastritis;
Immune checkpoint inhibitors;
Lung neoplasms
- MeSH:
Humans;
Adenocarcinoma of Lung/drug therapy*;
Cytomegalovirus/physiology*;
Cytomegalovirus Infections;
Gastritis/diagnosis*;
Immune Checkpoint Inhibitors/therapeutic use*;
Lung Neoplasms/drug therapy*
- From:
Chinese Journal of Lung Cancer
2025;28(8):644-646
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors (ICIs) have been approved for the treatment of a variety of solid tumors and hematological malignancies. Adverse reactions caused by ICIs have been gradually focused on. Cytomegalovirus (CMV) gastritis after ICIs treatment is relatively rare. Here we reported a case of advanced lung adenocarcinoma who experienced recurrent upper abdominal pain and vomiting after Pembrolizumab treatment. CMV gastritis was diagnosed through gastroscopy. The patient's symptoms improved after antiviral treatment. During the treatment of ICIs, attention should be paid to the differential diagnosis of upper abdominal pain symptoms, and vigilance should be maintained against CMV gastritis. It is difficult to differentiate CMV gastritis and immune-related gastritis judging from symptoms, and gastroscopy is important for differential diagnosis.
.
