Advances in Diagnosis and Targeted Therapy of KRASG12C Mutant
Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2025.101.13
- Author:
Jiahe SHI
1
;
Yufang WANG
1
;
Jing ZHENG
1
;
Jianya ZHOU
1
Author Information
1. Department of Respiratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University,
Hangzhou 310000, China.
- Publication Type:English Abstract
- Keywords:
Genetic testing;
Kirsten rat sarcoma viral oncogene;
Lung neoplasms;
Targeted therapy
- MeSH:
Humans;
Carcinoma, Non-Small-Cell Lung/drug therapy*;
Lung Neoplasms/drug therapy*;
Proto-Oncogene Proteins p21(ras)/genetics*;
Mutation;
Molecular Targeted Therapy
- From:
Chinese Journal of Lung Cancer
2025;28(8):597-611
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer stands as the primary cause of cancer-related mortalities globally, presenting a severe menace to human health. In individuals with non-small cell lung cancer (NSCLC), Kirsten rat sarcoma viral oncogene (KRAS) mutations serve as crucial oncogenic drivers. NSCLC with KRASG12C mutation is among the most prevalent subtypes. Currently, the detection methods for KRAS mutations predominantly concentrate on polymerase chain reaction (PCR) and sequencing platforms. The diverse derivative technologies of these two platforms each exhibit distinct merits and demerits in terms of testing performance and detection throughput, and find significant applications in tissue biopsy and liquid biopsy. In targeted therapies, KRASG12C targeted drugs, including Sotorasib, Adagrasib, Fulzerasib, Garsorasib, and Glecirasib, have demonstrated certain therapeutic efficacies in clinical trials and have obtained marketing approval. To tackle drug resistance and enhance patient's prognoses, combination therapeutic strategies that integrate targeted agents with chemotherapy, immune checkpoint inhibitors, Src homology region 2 domain-containing phosphatase 2 (SHP2) inhibitors, and epidermal growth factor receptor (EGFR) monoclonal antibodies have emerged. This paper systematically reviews the advancements in the diagnosis and targeted therapy of NSCLC with KRASG12C mutation, aiming to offer a reference for the selection of clinical treatment regimens and subsequent research.
.
