A Case of Endometrial Metastasis in Lung Adenocarcinoma
after EGFR-TKIs Treatment Failure and Literature Review.
10.3779/j.issn.1009-3419.2025.102.27
- Author:
Fangqian SHEN
1
;
Zuling HU
2
;
Hua YANG
3
;
Puyu LIU
3
;
Yuju BAI
1
;
Jianguo ZHOU
1
;
Hu MA
1
Author Information
1. Department of Thoracic Oncology,
The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
2. Department of Abdominal Oncology,
The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
3. Department of Pathology,
The Second Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
- Publication Type:English Abstract
- Keywords:
EGFR-TKIs;
Endometrial neoplasm;
Immunohistochemistry;
Lung neoplasms;
Tumor metastasis
- MeSH:
Humans;
Female;
ErbB Receptors/metabolism*;
Endometrial Neoplasms/genetics*;
Lung Neoplasms/genetics*;
Protein Kinase Inhibitors/therapeutic use*;
Adenocarcinoma of Lung/drug therapy*;
Treatment Failure;
Middle Aged;
Adenocarcinoma/genetics*
- From:
Chinese Journal of Lung Cancer
2025;28(7):551-557
- CountryChina
- Language:Chinese
-
Abstract:
The incidence and mortality rates of lung cancer remain high, making it the leading cause of cancer-related deaths. In women, the predominant histological subtype is lung adenocarcinoma, commonly associated with epidermal growth factor receptor (EGFR) mutations, and EGFR-tyrosine kinase inhibitors (EGFR-TKIs) can significantly improve patient prognosis. Metastasis of primary lung cancer to the endometrium is extremely rare and is often misdiagnosed as a primary reproductive system tumor, and its occurrence indicates poor prognosis. This article reports a case of an advanced lung adenocarcinoma patient with EGFR mutation, who developed abnormal vaginal bleeding after EGFR-TKIs treatment failure, and biopsy confirmed endometrial metastasis. A review of similar cases is also presented.
.
