Research Progress on the Role of Notch Signaling Pathway in Small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2025.106.17
- Author:
Feixue GU
1
;
Kaiyue ZHAO
1
;
Hengshuo YAN
1
;
Dongxin SUI
2
Author Information
1. The Second Clinical College, Shandong University, Jinan 250033, China.
2. Department of Respiratory Medicine, Second Hospital of Shandong University, Jinan 250033, China.
- Publication Type:English Abstract
- Keywords:
Lung neoplasms;
Molecular mechanisms;
Notch signaling pathway
- MeSH:
Humans;
Receptors, Notch/genetics*;
Signal Transduction;
Small Cell Lung Carcinoma/pathology*;
Lung Neoplasms/pathology*;
Animals
- From:
Chinese Journal of Lung Cancer
2025;28(7):513-520
- CountryChina
- Language:Chinese
-
Abstract:
Small cell lung cancer (SCLC), a highly aggressive subtype of lung cancer that originates from pulmonary neuroendocrine cells, accounts for 10% to 15% of all lung cancers. It is characterized by a high rate of early metastasis and extremely poor prognosis, often accompanied by challenges such as drug resistance and recurrence. Related researches indicates that the Notch signaling pathway plays a crucial role in the occurrence and development of SCLC by regulating processes such as cell proliferation, differentiation, and apoptosis. In SCLC, abnormal Notch signaling may promote tumor malignancy and the occurrence of drug resistance. Additionally, the Notch pathway is involved in the epithelial-mesenchymal transition of SCLC and influences immune escape mechanisms through interactions with the tumor immune microenvironment. This article reviews the molecular mechanisms of Notch signaling in SCLC, including the roles of its receptors and ligands, signal transduction processes, and its role in tumorigenesis. It also discusses the research progress of Notch signaling as a potential therapeutic target and looks forward to future research directions in this field.
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