A Case Report of Coexistence of EGFR and ROS-1 Gene Mutations
in Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2025.102.26
- Author:
Juan ZHAO
1
;
Jiaofeng YU
1
;
Ye FU
1
;
Yan ZHAO
1
;
Mingli ZHAO
1
Author Information
1. Kunming Medical University, Kunming 650500, China.
- Publication Type:English Abstract
- Keywords:
Case report;
Co-mutation;
EGFR;
Lung neoplasms;
ROS-1
- MeSH:
Humans;
Carcinoma, Non-Small-Cell Lung/enzymology*;
Lung Neoplasms/enzymology*;
ErbB Receptors/genetics*;
Mutation;
Protein-Tyrosine Kinases/genetics*;
Proto-Oncogene Proteins/genetics*;
Male;
Middle Aged;
Female
- From:
Chinese Journal of Lung Cancer
2025;28(6):482-486
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer represents one of the most prevalent malignant tumors globally, and its treatment has entered the era of targeted therapy. The epidermal growth factor receptor (EGFR) mutation is a common type of genetic mutation in non-small cell lung cancer (NSCLC), while c-ros oncogene 1 receptor tyrosine kinase (ROS-1) fusion mutation is a rare mutation site. Currently, there are few case reports on the coexistence of EGFR and ROS-1 gene mutations. This study reports a case of NSCLC with coexisting EGFR and ROS-1 gene mutations, aiming to provide relevant treatment strategies for clinical practice.
.
