Research Progress and Applications of ZDHHC-mediated Protein Palmitoylation
in the Development and Immune Escape of Non-small Cell Lung Cancer.
10.3779/j.issn.1009-3419.2025.102.15
- Author:
Wangcheng CHEN
1
;
Lili PANG
2
;
Yuemei LAN
2
;
Yanhong SHI
1
;
Bingbing WEN
1
;
Baihong ZHANG
2
Author Information
1. Northwest Minzu University College of Medicine, Lanzhou 730050, China.
2. Department of Oncology, the 940th Hospital of Joint Logistic Support Force
of Chinese People's Liberation Army, Lanzhou 730050, China.
- Publication Type:English Abstract
- Keywords:
Immune escape;
Lung neoplasms;
PD-L1;
Protein palmitoylation;
ZDHHC enzymes
- MeSH:
Humans;
Lipoylation;
Lung Neoplasms/pathology*;
Acyltransferases/genetics*;
Carcinoma, Non-Small-Cell Lung/pathology*;
Animals
- From:
Chinese Journal of Lung Cancer
2025;28(4):319-324
- CountryChina
- Language:Chinese
-
Abstract:
Non-small cell lung cancer (NSCLC), a leading cause of cancer-related deaths worldwide, remains a significant clinical challenge despite advances in immune checkpoint inhibitors therapy, with drug resistance persisting as a major obstacle. Palmitoylation, a critical post-translational modification (PTM) primarily catalyzed by palmitoyltransferases of the zinc finger DHHC-type (ZDHHC), has recently demonstrated important implications in NSCLC. This review aims to elucidate the mechanisms and clinical potential of ZDHHC-mediated protein palmitoylation in NSCLC progression and immune escape.
.
