Research Progress of Neutrophil Extracellular Traps in Lung Cancer.

Xu HAO; Yilin FENG; Anqi LU; Ying SUN; Jinchan XIA; Xue MEI; Long FENG; Min JIANG; Baiyan WANG; Huitong YANG

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Research Progress of Neutrophil Extracellular Traps in Lung Cancer.

Author: Xu HAO ¹ ; Yilin FENG ¹ ; Anqi LU ¹ ; Ying SUN ¹ ; Jinchan XIA ¹ ; Xue MEI ¹ ; Long FENG ¹ ; Min JIANG ¹ ; Baiyan WANG ¹ ; Huitong YANG ¹
Author Information

1. Medical College of Henan University of Chinese Medicine, Zhengzhou 450046, China.
Publication Type:English Abstract
Keywords: Lung neoplasms; Neutrophil extracellular traps; Tumor associated neutrophils; Tumor microenvironment
MeSH: Extracellular Traps/immunology*; Humans; Lung Neoplasms/metabolism*; Neutrophils/metabolism*; Animals; Tumor Microenvironment
From: Chinese Journal of Lung Cancer 2025;28(3):201-212
CountryChina
Language:Chinese
Abstract: Neutrophil extracellular traps (NETs), intricate reticular structures released by activated neutrophils, play a pivotal regulatory role in the pathogenesis of malignant tumors. Lung cancer is one of the most prevalent malignancies globally, with persistently high incidence and mortality rates. Recent studies have revealed that NETs dynamically modulate the tumor microenvironment through unique pathological mechanisms, exhibiting complex immunoregulatory characteristics during the progression of lung cancer, and this discovery has increasingly become a focal point in tumor immunology research. This paper provides a comprehensive review of the latest advancements in NETs research related to lung cancer, offering an in-depth analysis of their impact on lung cancer progression, their potential diagnostic value, and the current state of research on targeting NETs for lung cancer prevention and treatment. The aim is to propose novel strategies to enhance therapeutic outcomes and improve the prognosis for lung cancer patients. .