Research Progress on Molecular Subtypes and Precision Therapy
of Pulmonary Large Cell Neuroendocrine Carcinoma.
10.3779/j.issn.1009-3419.2025.102.06
- Author:
Yuchao FENG
1
;
Xiaohong CAO
2
Author Information
1. Shanxi Medical University, Taiyuan 030001, China.
2. Shanxi Fenyang Hospital, Fenyang 032299, China.
- Publication Type:English Abstract
- Keywords:
Immunotherapy;
Lung neoplasms;
Molecular subtype;
Precision therapy;
Pulmonary large cell neuroendocrine carcinoma;
Targeted therapy
- MeSH:
Humans;
Lung Neoplasms/drug therapy*;
Carcinoma, Neuroendocrine/drug therapy*;
Precision Medicine;
Immunotherapy;
Carcinoma, Large Cell/drug therapy*
- From:
Chinese Journal of Lung Cancer
2025;28(2):146-154
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a high-grade neuroendocrine tumor with unique characteristics, and its treatment regimens are primarily derived from those for small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In recent years, the incidence rate has been on the rise, and the prognosis are affected by the interaction of multiple factors such as individual, clinical stage and treatment mode, and the heterogeneity is significant. In the study of molecular subtypes, multiple subgroups were divided according to key gene mutations such as RB1 and TP53, and genomic subtypes were associated with survival, chemotherapy response, and efficacy of precision therapy. Targeted therapy excavates multiple targets, and the efficacy of drugs is different. Immunotherapy has made remarkable progress, and immune checkpoint inhibitors (ICIs) have been effective in all stages of chemotherapy alone or in combination with chemotherapy or radiation therapy, but there is a risk of hyperprogressive diseases, and accurate prognostic markers need to be explored urgently. This review reviews the latest research progress in the study of molecular subtypes and precision therapies such as targeted therapy and immunotherapy of pulmonary LCNEC, and points out that pulmonary LCNEC treatment will develop in the direction of precision and individualization in the future.
.
