Crosstalk between Tumor Cells and Neural Signals in Neuroendocrine Carcinoma
Metastasis: Communication Hijacking Based Perspective.
10.3779/j.issn.1009-3419.2025.101.03
- Author:
Shuping SONG
1
;
Xinyi WANG
2
;
Siqi ZHOU
3
;
Xuchen CHENG
3
;
Weixuan LIN
3
;
Yongxuan WANG
3
;
Yanqin SUN
1
Author Information
1. Department of Cancer Center, The Affiliated Dongguan Songshan Lake Central Hospital of Guangdong Medical University,
Dongguan 523808, China.
2. Department of Pathology, Guangdong Medical University, Zhanjiang 524000, China.
3. The First Clinical Medical College, Guangdong Medical University, Zhanjiang 524000, China.
- Publication Type:English Abstract
- Keywords:
Cancer neuroscience;
Communication hijacking;
Crosstalk effect;
Neuroendocrine carcinoma;
Tumor metastasis
- MeSH:
Humans;
Carcinoma, Neuroendocrine/metabolism*;
Signal Transduction;
Animals;
Neoplasm Metastasis;
Neurons/pathology*;
Tumor Microenvironment;
Cell Communication
- From:
Chinese Journal of Lung Cancer
2025;28(2):138-145
- CountryChina
- Language:Chinese
-
Abstract:
Neuroendocrine carcinoma (NEC) represents a category of malignant tumors originating from neuroendocrine cells. Given that NEC cells exhibit characteristics of both neural and endocrine cells, they can hijack neuronal signaling pathways and dynamically regulate the expression of neuronal lineage markers during tumor metastasis, thereby constructing a microenvironment conducive to tumor growth and metastasis. Conversely, alterations in the tumor microenvironment can enhance the interactions between neurons and tumor cells, ultimately synergistically promoting the metastasis of NEC. This review highlights recent advancements in the field of cancer neuroscience, uncovering neuronal lineage markers in NEC that facilitate tumor dissemination through mediating crosstalk, bidirectional communication, and synergistic interactions between tumor cells and the nervous system. Consequently, the latest findings in tumor neuroscience have enriched our understanding of the biological mechanisms underlying tumor metastasis, opening new research avenues for a deeper comprehension of the complex biological processes involved in tumor metastasis, particularly brain metastasis. This review provides a comprehensive review of the crosstalk between tumor cells and neural signaling in the metastasis of NEC.
.
