Dual Roles of Neutrophil Extracellular Traps in Lung Cancer:
Mechanism Exploration and Therapeutic Prospects.
10.3779/j.issn.1009-3419.2025.101.01
- Author:
Chengdao LI
1
;
Dongge PENG
1
;
Wei SUN
1
Author Information
1. Department of Thoracic Surgery II, Second Affiliated Hospital of Hainan Medical University, Haikou 570311, China.
- Publication Type:English Abstract
- Keywords:
Lung neoplasms;
Neutrophil;
Neutrophil extracellular traps
- MeSH:
Extracellular Traps/metabolism*;
Humans;
Lung Neoplasms/drug therapy*;
Neutrophils/immunology*;
Animals;
Tumor Microenvironment
- From:
Chinese Journal of Lung Cancer
2025;28(1):63-68
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common and lethal malignancies in China. In the context of the tumor microenvironment, neutrophil extracellular traps (NETs) released by neutrophils exert a profound impact on the occurrence and progression of lung cancer. Although the exact mechanisms by which NETs promote tumor growth have not been fully elucidated, existing research has revealed their multiple roles in tumor growth, invasion, metastasis, and cancer-related thrombosis. This article will review the molecular biology mechanisms and research progress of NETs in lung cancer based on recent studies.
.
