Research Progress of Tumor-associated Neutrophils
in the Occurrence and Development of Lung Cancer.
10.3779/j.issn.1009-3419.2025.101.02
- Author:
Xiaoyan LI
1
;
Jianjun ZHOU
2
;
Chaoting ZHAO
2
;
Yudi ZHANG
2
Author Information
1. Chongqing Qijiang Hospital of Traditional Chinese Medicine, Chongqing 401420, China.
2. College of Combination of Chinese
and Western Medicine, Chongqing University of Chinese Medicine, Chongqing 402760, China.
- Publication Type:English Abstract
- Keywords:
Immunity;
Lung neoplasms;
Tumor microenvironment;
Tumor-associated neutrophils
- MeSH:
Humans;
Neutrophils/pathology*;
Lung Neoplasms/pathology*;
Tumor Microenvironment;
Animals
- From:
Chinese Journal of Lung Cancer
2025;28(1):55-62
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the malignant tumor with the highest mortality rate worldwide. The tumor microenvironment (TME) is a key factor in the progression of lung cancer, composed of tumor cells, signaling molecules, fibroblasts, immune cells, etc. Among them, tumor associated neutrophil (TAN), as an important component of immune cells in the TME, plays multiple roles in tumor cell proliferation, invasion, angiogenesis, and metastasis due to its aberrant function, and is closely associated with poor prognosis. However, there are limited researches on the mechanism of TAN in lung cancer. This review aims to provide more scientific basis for studying the therapeutic targets of lung cancer and developing new drugs by elucidating the different subtypes of TAN and their mechanisms of action in the occurrence and development of lung cancer.
.
