Research Progress of Epigenetic Modification in Hematopoietic Stem Cell Functional Regulation--Review.
10.19746/j.cnki.issn.1009-2137.2025.05.042
- Author:
Chun-Yuan LIANG
1
;
Rui-Ting WEN
1
;
Zhi-Gang YANG
1
Author Information
1. Department of Hematology, Zhanjiang Central Hospital, Guangdong Medical University, Zhanjiang 524045, Guangdong Province, China.
- Publication Type:English Abstract
- Keywords:
epigenetic modification；hematopoietic stem cell；development；functional regulation；expansion
- MeSH:
Hematopoietic Stem Cells;
Epigenesis, Genetic;
Humans;
DNA Methylation
- From:
Journal of Experimental Hematology
2025;33(5):1529-1533
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, with the development of single-cell sequencing technology, spatial transcriptome technology and in vivo tracing technology, scientists have a deeper understanding of scientific issues about the in vivo development, functional regulation and ex vivo expansion of hematopoietic stem cells (HSCs). Among them, epigenetic modification plays an important role in the development and fate decisions, function maintenance and ex vivo expansion of HSCs, which has become a research hotspot in the field of stem cells in recent years. This article reviews the recent research progress of epigenetic modification in the development, functional regulation and expansion of HSCs.
