Analysis of Hormone Levels in Patients with Hematological Diseases Before and After Hematopoietic Stem Cell Tansplantation.
10.19746/j.cnki.issn.1009-2137.2025.05.031
- Author:
Fen LI
1
;
Yu-Jin LI
1
;
Jie ZHAO
1
;
Zhi-Xiang LU
1
;
Xiao-Li GAO
1
;
Hai-Tao HE
1
;
Xue-Zhong GU
1
;
Feng-Yu CHEN
1
;
Hui-Yuan LI
1
;
Qi SA
1
;
Lin ZHANG
1
;
Peng HU
1
Author Information
1. Department of Hematology, The First People's Hospital of Yunnan Province/ Yunnan Province Clinical Research Center for Hematologic Diseases and Thrombosis Prevention and Treatment/ Hu Yu Expert Workstation/ Yunnan Province Major Complicated Diseases Traditional Chinese and Western Medicine Clinical Collaboration Pilot Project-Leukemia, Kunming 650000, Yunnan Province, China.
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
endocrine function;
thyroid hormones;
reproductive hormones;
adrenocorticotropic hormone
- MeSH:
Humans;
Hematopoietic Stem Cell Transplantation;
Female;
Male;
Hematologic Diseases/blood*;
Follicle Stimulating Hormone/blood*;
Triiodothyronine/blood*;
Luteinizing Hormone/blood*;
Thyroid Gland/metabolism*;
Estradiol/blood*;
Thyrotropin/blood*;
Gonads/metabolism*;
Adult;
Middle Aged;
Adrenocorticotropic Hormone/blood*;
Hormones/metabolism*;
Adrenal Cortex/metabolism*;
Prolactin
- From:
Journal of Experimental Hematology
2025;33(5):1443-1452
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:By analyzing the hormone secretion of the adenohypophysis, thyroid glands, gonads, and adrenal cortex in patients with hematological diseases before and after hematopoietic stem cell transplantation (HSCT), this study aims to preliminarily explore the effect of HSCT on patients' hormone secretion and glandular damage.
METHODS:The baseline data of 209 hematological disease patients who underwent HSCT in our hospital from January 2019 to December 2023, as well as the data on the levels of hormones secreted by the adenohypophysis, thyroid glands, gonads and adrenal cortex before and after HSCT were collected, and the changes in hormone levels before and after transplantation were analyzed.
RESULTS:After allogeneic HSCT, the levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3) and estradiol (E2) decreased, while the levels of luteinizing hormone (LH) and follicle- stimulating hormone (FSH) increased. The T3 level of patients with decreased TSH after transplantation was lower than that of those with increased TSH after transplantation. In female patients, the levels of prolactin (PRL), progesterone (Prog), and testosterone (Testo) decreased after HSCT. Testo and PRL decreased when there was a donor-recipient sex mismatch, and the levels of adrenocorticotropic hormone (ACTH) and cortisol (COR) decreased when the HLA matching was haploidentical. The levels of T3, FT3, and PRL decreased after autologous HSCT. In allogeneic HSCT patients, the levels of TSH, T4, T3, FT3, and ACTH in the group with graft-versus-host disease (GVHD) were significantly lower than those in the group without GVHD. Logistic regression analysis showed the changes in hormone levels after transplantation were not correlated with factors such as the patient's sex, age, or whether the blood types of the donor and the recipient are the same.
CONCLUSION:HSCT can affect the endocrine function of patients with hematological diseases, mainly affecting target glandular organs such as the thyroid, gonads, and adrenal glands, while the secretory function of the adenohypophysis is less affected.
