Correlation of ARID5B Gene Polymorphism and Risk of Childhood Acute Lymphoblastic Leukemia and Minimal Residual Disease.
10.19746/j.cnki.issn.1009-2137.2025.05.005
- Author:
Yu MA
1
;
Ya-Dai GAO
2
;
Jing GUO
2
;
Xiao-Min ZHENG
3
;
Xiao-Chun ZHANG
1
Author Information
1. Department of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan 750001, Ningxia Hui Autonomous Region, China.
2. Department of Respiratory, Yinchuan Women and Children Healthcare Hospital, Yinchuan 750001, Ningxia Hui Autonomous Region, China.
3. Rehabilitation Medicine Center, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750001, Ningxia Hui Autonomous Region, China.
- Publication Type:Journal Article
- Keywords:
children;
acute lymphoblastic leukemia
- MeSH:
Humans;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*;
Polymorphism, Single Nucleotide;
Case-Control Studies;
Neoplasm, Residual/genetics*;
DNA-Binding Proteins/genetics*;
Transcription Factors/genetics*;
Genotype;
Genetic Predisposition to Disease;
Gene Frequency;
Child;
Male;
Female;
Alleles;
Risk Factors;
Child, Preschool
- From:
Journal of Experimental Hematology
2025;33(5):1269-1273
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation between single nucleotide polymorphisms (SNPs) of ARID5B gene and the risk of acute lymphoblastic leukemia (ALL) and minimal residual disease (MRD) in children of Hui and Han nationality in Ningxia.
METHODS:In this case-control study, 54 ALL children and control group with matched age, sex and nationality were detected for the polymorphism of ARID5B gene using fluorescence resonance energy transfer technique, and the susceptibility of different ALL genotypes and their correlation with MRD were analyzed.
RESULTS:There were no significant differences in genotype and allele frequency of rs10994982, rs7089424, rs10740055, rs7073837, rs4245595 and rs7090445 between the two groups (P >0.05). At the locus of rs10821936, the frequencies of T/T genotype and T allele in ALL group were significantly higher than those in the control group (both P < 0.05). The C/C genotype of ARID5B gene SNP rs10821936 was a risk factor for early MRD positive in ALL children ( P < 0.05).
CONCLUSION:ARID5B gene SNP rs10821936 is related to the development of childhood ALL and MRD.
