Silent α-Thalassemia Complicated with the Alcohol-Induced Secondary Ring Sideroblastic Anemia.
10.19746/j.cnki.issn.1009-2137.2025.04.024
- Author:
Yan JIANG
1
;
Ya CHEN
1
;
Lan YANG
1
;
Wei-Bin LI
1
Author Information
1. Department of Clinical Laboratory, The 900th Hospital of Joint Logistics Support Force, PLA (Fuzhou General Clinical Medical School, Fujian Medical University; Fuzhou General Teaching Hospital, Fujian University of Traditional Chinese Medicine), Fuzhou 350025, Fujian Province, China.
- Publication Type:English Abstract
- Keywords:
sideroblastic anemia;
myelodysplastic syndrome;
alcohol
- MeSH:
Humans;
Anemia, Sideroblastic/complications*;
alpha-Thalassemia/complications*;
Retrospective Studies;
Male
- From:
Journal of Experimental Hematology
2025;33(4):1094-1097
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the characteristics of laboratory examination of secondary sideroblastic anemia (SA).
METHODS:A retrospective analysis was conducted on the general information of a case of alcohol-induced secondary SA, and relevant domestic and foreign literature was reviewed to summarize the clinical characteristics of this disease.
RESULTS:The patient was diagnosed with microcytic hypochromic anemia, with abnormal red blood cells detected, such as elliptocytes, target cells, and teardrop cells, etc. Iron overload and more than 15% of ring sideroblasts were detected by Perls' Prussian blue staining of bone marrow smear, while periodic acid-schiff (PAS) staining, EGR1 and SF3B1 gene tests were all negative, and rare genotype of Hong Kong α-thalassemia (possibly HKαα/αα or HKαα/-α3.7) was observed.
CONCLUSION:Patient medical history and medication history, peripheral blood and bone marrow cytological morphology, genetic testing, cytogenetics, etc. are helpful for the diagnosis of secondary SA.
