Application of Fine-Needle Aspiration in the Diagnosis of Classic Hodgkin Lymphoma and Its Clinical Pathological Analysis.
10.19746/j.cnki.issn.1009-2137.2025.04.017
- Author:
Lan CHEN
1
;
Zhou-Ying LIU
1
;
Zheng-Xian CHEN
1
;
Jin-Song ZHANG
1
Author Information
1. Department of Pathology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
classical Hodgkin lymphoma;
fine-needle aspiration;
immunocytochemical stain
- MeSH:
Humans;
Hodgkin Disease/pathology*;
Biopsy, Fine-Needle;
Retrospective Studies;
Female;
Immunohistochemistry;
Male
- From:
Journal of Experimental Hematology
2025;33(4):1047-1050
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the cytologic characteristics fine-needle aspiration using histology as the gold standard and to evaluate its diagnostic application in classic Hodgkin lymphoma.
METHODS:A retrospective analysis was conducted on 17 patients who underwent both coarse-needle aspiration and fine-needle aspiration and were histologically confirmed with classic Hodgkin lymphoma(CHL) at our hospital from December 2012 to December 2023. Clinical information of these patients was collected, and the smear morphology, immunocytochemistry and corresponding biopsies were reviewed.
RESULTS:Among the 17 cases of CHL, there were 5 cases of mixed cellularity, 10 cases of nodular sclerosis and 2 cases were unsubtyped. Fifteen cases were correctly diagnosed by fine-needle aspiration, with an accuracy rate of 88.2%. The other two cases were misdiagnosed as non-Hodgkin lymphoma. Morphologically single dispersed mononuclear Hodgkin cells and multinucleated Reed-Sternberg cells were observed in a heterogenous background of lymphocytes in cytology smears, and these cells were positive for CD30 immunocytochemistry.
CONCLUSION:Fine needle aspiration is less invasive and quicker, and the cell morphology is better preserved as compared to histological biopsy. It is easier to recognize pathognomonic Hodgkin or Reed-Sternberg cells and it is helpful for the rapid diagnosis and clinical management of CHL.
