Research Progress of the Wnt/β-catenin Signaling Pathway in the Regulation of Oxidative Stress and Its Impact on the Hematopoietic System --Review.
10.19746/j.cnki.issn.1009-2137.2025.03.047
- Author:
Yun-Xia NIU
1
;
Bo ZHENG
2
Author Information
1. First Clinical Medical College of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
2. Department of Hematology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
- Publication Type:English Abstract
- Keywords:
Wnt/β-catenin signaling pathway;
oxidative stress;
hematopoiesis
- MeSH:
Oxidative Stress;
Humans;
Wnt Signaling Pathway;
Hematopoietic Stem Cells;
Reactive Oxygen Species/metabolism*;
Hematopoietic System/metabolism*;
beta Catenin/metabolism*;
Hematopoiesis
- From:
Journal of Experimental Hematology
2025;33(3):927-930
- CountryChina
- Language:Chinese
-
Abstract:
Excessive generation of reactive oxygen species (ROS) can lead to oxidative-antioxidative imbalance in the organism, resulting in oxidative stress. Hematopoietic stem/progenitor cells (HSPCs) exhibit high sensitivity to changes in ROS levels, and high levels of ROS can impair self-renewal capacity of HSPCs, leading to oxidative damage and even death. Wnt/β-catenin signaling pathway regulates hematopoiesis and plays an important role in determining the fate of stem cells, such as self-renewal, proliferation and differentiation of HSPCs. Studies have shown that Wnt/β-catenin signaling pathway is also closely related to oxidative stress. This article summarizes the relevant literature, and reviews the role of Wnt/β-catenin signaling pathway in oxidative stress, its impact on hematopoietic system, and the current research status of related mechanisms.
