Clinical Characteristic of Castleman Disease with Renal and Orbit Involvement.
10.19746/j.cnki.issn.1009-2137.2025.03.042
- Author:
Yin-Qian LIU
1
;
You-Hai XU
2
;
He-Sheng HE
2
Author Information
1. Department of Nephrology,Yijishan Hospital of Wannan Medical College, Wuhu 241000, Anhui Province, China.
2. Department of Hematology, Yijishan Hospital of Wannan Medical College, Wuhu 241000, Anhui Province, China.
- Publication Type:English Abstract
- Keywords:
Castleman disease;
renal insufficiency;
orbital mass;
multiple serosal cavity effusion;
lymphadenectasi
- MeSH:
Humans;
Castleman Disease/diagnosis*;
Middle Aged;
Female;
Retrospective Studies;
Orbit/pathology*;
Kidney/pathology*
- From:
Journal of Experimental Hematology
2025;33(3):899-905
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical characteristics, diagnosis, and treatment methods of one patient with idiopathic multicentric Castleman disease (iMCD), in order to strengthen the understanding of this rare disease.
METHODS:The clinical manifestations, diagnosis and treatment process, and prognosis of one patient with iMCD admitted to our hospital were retrospectively analyzed.
RESULTS:The patient was a 45-year-old female with swollen bilateral orbit, edema of lower limbs, multiple serosal cavity effusion, thrombocytopenia, renal insufficiency, and multiple lymph node enlargement. Lymph node biopsy suggested mixed type of Castleman disease. Combined with pathology, imaging and laboratory examination, the patient was finally diagnosed with mixed type of iMCD. After six cycles of R-COP regimen chemotherapy, the patient achieved complete remission.
CONCLUSIONS:Castleman disease with renal and orbit involvement is rare in clinic and easy to be misdiagnosed. It should be distinguished from lymphoma. The patient has been treated with R-COP regimen, and obtained good short-term efficacy.
