Molecular Biological Mechanism and Transfusion Strategy of a Jk(a-b-) Family.
10.19746/j.cnki.issn.1009-2137.2025.03.037
- Author:
Xiao-Yan LI
1
;
Qiong-Fei DENG
1
;
Xiao-Li LAI
1
;
Dan-Dan CHEN
1
;
Dan WANG
1
;
Xuan ZENG
1
Author Information
1. Jiangxi Maternal and Child Health Hospital, Nanchang 330108, Jiangxi Province, China.
- Publication Type:Journal Article
- Keywords:
JK（a-b-）;
Kidd blood group
- MeSH:
Humans;
Blood Transfusion;
Female;
Kidd Blood-Group System/genetics*;
Phenotype;
Pedigree
- From:
Journal of Experimental Hematology
2025;33(3):869-874
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the molecular mechanism and explore blood transfusion strategies for a proband exhibiting the JK (a-b-) phenotype and anti-JK3 high frequency antigen antibody and her eight family members.
METHODS:The Kidd blood phenotype and irregular antibodies in a family were identified by serologic tests. Exon 4-11 and intron region of SLC14A1 gene were sequenced by Sanger method.
RESULTS:The combination of the gene JK*B (c.499A>G,c.512G>A,c.588A>G) and gene JK*B (c.342-1G>A,588A>G) in this family were considered to result in the JK (a-b-) phenotype in two members. The members carrying gene JK*A(c.130G>A,588A>G) all present serological JKa+W. Members carrying gene JK*B (c.499A>G,c.588A>G) all present serological JKb+W, which has not been previously reported to cause antigenic weakening. The proband with JK (a-b-) phenotype produced anti-JK3 antibodies, the hospital formulated a number of blood preparation strategies for the patient and she was discharged after recovery.
CONCLUSION:In this study, the molecular mechanism of JK (a-b-) in this family was identified, the transfusion strategy of rare blood group was established in our institution preliminary, and the necessity of establishing a rare blood group bank was revealed in this region. It is suggested that JK*B (c.499A>G,c.588A>G) may be a new genetic pattern leading to the weakening of Kidd antigenicity, which lays a foundation for the study of population genetics.
