Clinical Value of a Novel Prognostic Prediction Model in Diffuse Large B-Cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2025.03.024
- Author:
Jie ZHAO
1
;
Yan JIANG
1
;
Jia-Yu LIU
1
;
Rui LIU
1
;
Jia-Qi LI
1
;
Fang HUANG
1
;
Jiang-Bo WAN
1
;
Si-Guo HAO
1
Author Information
1. Department of Hematology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
- Publication Type:Journal Article
- Keywords:
diffuse large B-cell lymphoma;
clinical features;
immunophenotype;
prognostic prediction model
- MeSH:
Humans;
Lymphoma, Large B-Cell, Diffuse/diagnosis*;
Prognosis;
Proto-Oncogene Proteins c-bcl-2/metabolism*;
Risk Factors;
Male;
Female;
Middle Aged
- From:
Journal of Experimental Hematology
2025;33(3):789-795
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore a predictive model that can better predict the prognosis of patients with diffuse large B-cell lymphoma (DLBCL), and validate its clinical value.
METHODS:Clinical data of 134 newly treated DLBCL patients were collected from Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2015 to January 2020. Several risk factors of the patients were screened and analyzed, a novel prognostic model were then established based on this, and its clinical application potential was validated.
RESULTS:In the novel model, predicting progression-free survival (PFS) based on the age at initial treatment, albumin level, Hans classification, Ann Arbor stage, and BCL2 expression showed better predictive performance than International Prognostic Index (IPI) score (AUC: 0.788 vs 0.620，P <0.001). Predicting overall survival (OS) based on the age at initial treatment, albumin level, lactate dehydrogenase (LDH) level, and expressions of BCL2 and MUM1 proteins also showed better predictive performance for mortality risk than IPI score (AUC: 0.817 vs 0.624，P <0.001).
CONCLUSION:This novel prognostic model can better predict the survival prognosis of DLBCL patients compared to the IPI scoring system.
