Clinical Characteristics and Prognostic Analysis of Peripheral T-Cell Lymphoma, Not Otherwise Specified.
10.19746/j.cnki.issn.1009-2137.2025.03.019
- Author:
Guo-Xiang CHEN
1
;
Jian-Shu HAO
2
;
Xue BAI
3
;
Qing-Qing ZHANG
1
;
Hai-Xia AN
1
;
Xiu-Juan HUANG
4
;
Yan-Qing SUN
1
Author Information
1. The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China.
2. Department of Vascular Surgery, The First People's Hospital of Yinchuan, Yinchuan 750000, Ningxia Hui Autonomous Region, China.
3. Department of Gynecology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
4. Department of Hematology, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu Province, China.
- Publication Type:Journal Article
- Keywords:
peripheral T-cell lymphoma;
clinical features;
prognosis
- MeSH:
Humans;
Lymphoma, T-Cell, Peripheral/diagnosis*;
Male;
Prognosis;
Middle Aged;
Female;
Aged
- From:
Journal of Experimental Hematology
2025;33(3):753-759
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the clinical characteristics and prognosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS).
METHODS:Clinical data of 10 patients with PTCL-NOS in Gansu Provincial Hospital from May 2016 to June 2023 were collected. The treatment outcomes were evaluated, and the factors affecting prognosis were analyzed.
RESULTS:The median age of onset for the 10 patients was 60.7 (47-75) years, with 7 males and 3 females. Nine cases received chemotherapy, while one case died suddenly after diagnosis, and the median course of chemotherapy was 6.9 (1-13) courses. Assessing the efficacy, 3 patients achieved complete remission (CR) while 7 patients showed progression. Age, sex, lactate dehydrogenase (LDH) level, Ki-67 and the presence of hemophagocytic lymphohistocytosis (HLH) were not statistically correlated with CR rate ( P >0.05). Patients with IPI score 3-5, and Ann Arbor stage III-IV had statistically lower CR rates (both P <0.05). Age, B symptoms, LDH level ,hemoglobin, Ki-67 index and PLR value were not statistically correlated with overall survival (OS) time ( P >0.05). Male, platelet <150×109/L, IPI score 3-5, Ann Arbor stage III-IV, presence of HLH, NLR≥4.05, and LMR <2.81 were statistically correlated with shorter OS (all P <0.05). Among the 10 patients, 3 cases have survived and are still in CR status, while 7 cases have died, with a median survival time of 7.5 (1-85) months.
CONCLUSIONS:Patients with IPI score 3-5 and Ann Arbor stage III-IV have low CR rate and poor prognosis. The OS of patients who are male, with platelet <150×109/L, IPI score 3-5, Ann Arbor stage III-IV, complication of HLH, NLR≥4.05, and LMR <2.81 is short, and prognosis is poor.
