Clinical Characteristics and Prognosis of 7 Patients with T-Cell Large Granular Lymphocytic Leukemia.
10.19746/j.cnki.issn.1009-2137.2025.03.012
- Author:
Yong-Qian ZHANG
1
;
Yuan-Yuan ZHANG
2
;
Xiao-Fang WEI
3
;
You-Fan FENG
3
;
Yuan FU
3
;
Qiao-Lin CHEN
3
;
Qi-Ke ZHANG
3
;
Ji-Sheng ZHAO
1
Author Information
1. Department of Hematology, Qingyang Hospital, Qingyang 745000, Gansu Province, China.
2. The First Clinical College of Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China.
3. Department of Hematology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
- Publication Type:Journal Article
- Keywords:
T-cell large granular lymphocytic leukemia;
clinical characteristics;
treatment;
prognosis
- MeSH:
Humans;
Leukemia, Large Granular Lymphocytic/diagnosis*;
Male;
Middle Aged;
Female;
Aged;
Prognosis;
Adult;
Aged, 80 and over;
Retrospective Studies
- From:
Journal of Experimental Hematology
2025;33(3):706-710
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the clinical characteristics and prognosis of patients with T-cell large granular lymphocytic leukemia (T-LGLL).
METHODS:The clinical data of 7 patients with T-LGLL in Gansu Provincial Hospital from March 2016 to June 2023 were analyzed retrospectively.
RESULTS:Among the 7 patients, 5 were male and 2 were female, with a median age of 51(28-83) years old. At the onset of illness, 6 cases showed symptoms of fatigue and anemia, 4 cases had enlarged lymph nodes, and 5 cases had splenomegaly. Examination showed that 4 cases were antinuclear antibody(ANA) positive, 5 cases were anemia. The median hemoglobin (Hb) level was 83(61-151) g/L, the median white blood cell count (WBC) was 5.6(2.0-8.7)×109 /L, and the median percentage of lymphocytes in peripheral blood was 66.2(13.9-89.1)%. There were 3 cases with extremely active bone marrow hyperplasia, 2 cases with active hyperplasia, and 2 cases with decreased hyperplasia. There were 5 cases with mild myelofibrosis (MF-1), and 1 case with moderate myelofibrosis (MF-2). The median percentage of T cells was 64.3 (31.5-80.6)%. 5 cases showed the classic immunophenotype (CD3 + CD4- CD8 +), 6 cases were CD57 +, 3 cases were TCRα/β +, and 3 cases were TCRγ/δ +. TCRG rearrangement was detected in 5 cases.The median follow-up time was 55(4-87) months, one patient died of heart disease, and the other 6 patients are surviving.
CONCLUSION:The incidence of T-LGLL is low. The initial symptoms of T-LGLL include anemia, fatigue, lymph node enlargement, splenomegaly, and higher percentage of lymphocytes in peripheral blood, the percentage of abnormal T cells in bone marrow was significantly increased. Analysis of flow cytometric immunophenotyping, TCR gene rearrangement, and hot spot genes such as STAT3 and STAT5b, can improve the diagnostic accuracy.
