The Latest Research Progress of T Cell Exhaustion in Hematological Malignancy --Review.
10.19746/j.cnki.issn.1009-2137.2025.02.045
- Author:
Xia-Xin LIU
1
;
Zi-Zhen XU
2
;
Jun-Min LI
1
Author Information
1. Shanghai Institute of Hematology, Department of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
2. College of Health Science and Technology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:English Abstract
- Keywords:
T cell exhaustion;
hematological tumor;
immunotherapy
- MeSH:
Humans;
Hematologic Neoplasms/immunology*;
T-Lymphocytes/immunology*;
Tumor Microenvironment;
Immunotherapy;
T-Cell Exhaustion
- From:
Journal of Experimental Hematology
2025;33(2):606-611
- CountryChina
- Language:Chinese
-
Abstract:
T cell exhaustion plays an immunosuppressive role in malignant tumors. Continuous tumor antigen stimulation, the presence of suppressive immune cells and cytokines in the tumor microenvironment, the up regulation of inhibitory receptor expression on the surface of T cells, changes in T cell related transcription factors, and metabolites in the tumor microenvironment may lead to T cell exhaustion. Reversing the exhaustion of T cells in tumor patients is a promising strategy for tumor immunotherapy. This article will review the latest research progress on T cell exhaustion status, pathogenesis, reversal methods, and clinical applications in hematological tumors.
