The Mechanism of Iron in Lymphocyte and Plasma Cell Diseases--Review.
10.19746/j.cnki.issn.1009-2137.2025.02.044
- Author:
Shu-Lin LUO
1
;
Fei-Fei YANG
1
;
Yan-Li XU
1
Author Information
1. Department of Hematology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210000, Jiangsu Province, China.
- Publication Type:English Abstract
- Keywords:
lymphoma;
multiple myeloma;
iron metabolism;
ferroptosis
- MeSH:
Humans;
Iron/metabolism*;
Ferroptosis;
Multiple Myeloma/metabolism*;
Lymphoma/metabolism*;
Reactive Oxygen Species/metabolism*;
Lymphocytes
- From:
Journal of Experimental Hematology
2025;33(2):601-605
- CountryChina
- Language:Chinese
-
Abstract:
As an important trace element, iron is involved in a variety of physiological processes. In recent years, studies have found that the occurrence and development of tumors are closely related to abnormal iron metabolism, and the mode of action is obviously heterogeneous. Tumor cells need more iron to promote their survival and proliferation, but iron overload can also have adverse effects on tumor cells, such as ferroptosis. Ferroptosis is a special regulatory mechanism of cell death, which is different from other regulated cell death pathways. It mainly induces cell death through excessive accumulation of iron-dependent lipid peroxide and reactive oxygen species (ROS). Recent studies have found that in the blood system, tumor cells of lymphoma and multiple myeloma (MM) are more sensitive to ferroptosis and affect disease progression through a variety of mechanisms. In this review, the mechanisms of ferroptosis in some subtypes of lymphoma and MM are described in detail, and the correlation between ferroptosis of hematological tumor cells and the occurrence and development of hematological tumors is revealed, aiming to provide new ideas for the treatment of these hematological diseases.
