Study on Reentry Strategy and Results of Blood Donors with Single Reagent Reactivity in Wuhan Area.
10.19746/j.cnki.issn.1009-2137.2025.02.033
- Author:
Ting-Ting XU
1
;
Qin YU
1
;
Song-Qing KE
1
;
Yan CAI
1
;
Song-Li XIE
1
;
Jing XIONG
1
;
Lei ZHAO
1
Author Information
1. Wuhan Blood Center, Wuhan 430030, Hubei Province, China.
- Publication Type:Journal Article
- Keywords:
blood donations;
blood donor reentry;
reentry strategy;
supplementary testing;
confirmatory testing
- MeSH:
Humans;
Blood Donors;
China;
Hepatitis B;
Enzyme-Linked Immunosorbent Assay;
Hepatitis C;
Male
- From:
Journal of Experimental Hematology
2025;33(2):530-537
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the results, re-donation situation and characteristics of single-reagent reactive blood donors who were put into the reentry strategy in Wuhan area, explore the rationality and effectiveness of the current reentry strategy, and provide data support for the improvement of the reentry process of blood donors.
METHODS:From January 2020 to December 2023, blood donors who conform the reentry criteria and voluntarily applied for returning to Wuhan Blood Center were tested and the results were analyzed. According to the reentry strategy, serological testing and nucleic acid testing were carried out in parallel, serological testing was performed by ELISA with reagents from two different manufacturers, and the primary reactive samples were tested by double-well retest, and HBV/HCV/HIV nucleic acid detection was performed by RT-PCR with an individual donor test mode. Supplementary HBcAb testing was applied for HBV single reagent reactivity by chemiluminescence method. Supplementary TP-WB testing was applied for returning blood donors with repeated TP single reagent reactivity. If returning blood donors with HIV single reagent reactivity were repeated single reagent reactivity, the samples were sent to local CDC for confirmatory test.
RESULTS:7 098 blood donors were qualified for reentry, 716 donors voluntarily applied for reentry, 436 donors successfully reentry, 251 donors entered the next round, 29 donors could not reentry. The reentry rates for the past four years were 66.67%（42/63）, 54.73%（81/148）, 60.71%（136/224） and 62.99%（177/281）, respectively. Up to December 31, 2023, 275 donors donated blood again, and the donation rates for past four years were 76.19%（32/42）, 72.84%（59/81）, 61.76%（84/136） and 56.50%（100/177）, respectively. After donating blood, 31 donors were disqualified again by blood screening and subjected to permanent deferral. The results of returning to the team had statistical differences in reentry items, educational level, age, and marriage（P < 0.05）.
CONCLUSION:The current reentry strategy adopted by the blood donation and supply institution can effectively retain part of blood donors, reduce the negative emotions of blood donors and increase blood resources.
