Screening of High-Titer IgG Antibodies to 2019-nCoV among Voluntary Blood Donors in Zunyi.
10.19746/j.cnki.issn.1009-2137.2025.02.032
- Author:
Liang-Xue WEN
1
;
Li SU
1
;
Sheng-Jun ZENG
1
;
Lan-Yi ZHANG
1
;
Si-Hai HUANG
1
Author Information
1. Department of Clinical Laboratory, Zunyi Blood Center, Zunyi 563000, Guizhou Province, China.
- Publication Type:Journal Article
- Keywords:
voluntary blood donors;
2019 novel coronavirus（2019-nCoV）;
IgG antibody
- MeSH:
Humans;
Blood Donors;
Immunoglobulin G/blood*;
Antibodies, Viral/blood*;
SARS-CoV-2/immunology*;
COVID-19;
Female;
Enzyme-Linked Immunosorbent Assay;
Adult;
China;
Male;
Middle Aged
- From:
Journal of Experimental Hematology
2025;33(2):526-529
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the serological prevalence of high-titer IgG antibodies against 2019-nCoV among voluntary blood donors in Zunyi.
METHODS:The blood plasma specimens were diluted at 1∶160 or 1∶320, then tested for the presence of 2019-nCoV IgG antibodies by using an indirect enzyme-linked immunosorbent assay(ELISA). The differences of antibody reactive rate among different genders, ages, and blood types were analyzed.
RESULTS:1 523 reactive specimens were identified in 5 378 specimens which were diluted at a ratio of 1∶160. Similarly, 329 reactive specimens were identified in 2 988 diluted at 1∶320. The overall reactive rate for antibodies was 22.1%. It was observed that females, individuals over the age of 40, and those with blood type AB exhibited higher high-titer antibody reactive rate.
CONCLUSION:After entering a new stage of 2019-nCoV infection prevention and control, there is a relatively high detection rate of high-titer 2019-nCoV IgG antibodies among voluntary blood donors in Zunyi. The reactive rate of antibodies varies among different genders, ages, and blood types.
