Analysis of the Influencing Factors of ABO Blood Group Antibody Origin and Titer in Neonates.
10.19746/j.cnki.issn.1009-2137.2025.02.031
- Author:
Meng-Jiao YANG
1
;
Li ZHANG
2
;
Yu ZHOU
1
;
Chun YANG
1
;
Xiang SHI
1
Author Information
1. Blood Transfusion Department, Shuangliu District First People's Hospital/Sichuan University West China Airport Hospital, Chengdu 610200, Sichuan Province, China.
2. Department of Blood Transfusion Medicine, The General Hospital of Western Theater Command， Chengdu 610083， Sichuan Province, China.
- Publication Type:Journal Article
- Keywords:
neonate;
ABO blood type;
antibody titer
- MeSH:
Humans;
Infant, Newborn;
ABO Blood-Group System/immunology*;
Female;
Immunoglobulin G/blood*;
Immunoglobulin M/blood*;
Pregnancy;
Blood Grouping and Crossmatching
- From:
Journal of Experimental Hematology
2025;33(2):520-525
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the origin and influencing factors the titer of ABO blood group antibody in neonates.
METHODS:A total of 303 newborn blood samples collected in our hospital from August 2023 to March 2024 were selected for the detection of ABO blood group settings and the determination of the total titers of IgG and IgM blood group antibodies in plasma. IgM antibodies were treated with dithithreitol (DTT) to determine the titers of IgG antibodies. The total titer of the blood group antibody was compared with that of the IgG antibody. The clinical data of mothers and newborns were collected, and the correlation between the antibody titer and these clinical data was analyzed.
RESULTS:Among the 303 newborn specimens, 14 cases (4.62%) were identified to possess blood group antibodies. The influence of the maternal ABO blood group on the generation of high-potency blood group antibodies in newborns was observed to follow the order of O>B>A>AB, with a significant statistical difference ( P < 0.01). Of the 123 (40.59%) newborns born to mothers of type O, 121 (98.37%) had blood group antibody titers > 2. Of the 20 (6.60%) newborns born to mothers of type AB, all 20 (100.00%) had blood group antibody titers < 2. Among 89 (29.37%) mothers of type A and 71 (23.43%) mothers of type B, the titer of 100% newborn blood group antibody was less than 2, when the newborn blood group was incompatible with the mother's blood group; the titer of the newborn blood type antibody was higher or lower, when the newborn blood type was compatible with the mother's blood type. The titer of the newborn blood group antibodies is related to the number of pregnancies of the mothers and has no association with other clinical data (such as the mother's number of obortions), the number of production, fetal gestation age.
CONCLUSION:The majority of ABO blood group antibodies in neonates are IgG antibodies from the mothers, and few are produced by the neonates themselves. In some neonates, IgG anti-A and/or anti-B can agglutinate with anti-stereotyped cells at room temperature. The maternal ABO blood type is the primary factor influencing the titer of the newborn blood type. The number of maternal pregnancies is a factor affecting the high titer ABO blood group antibodies in newborns.
