Recent Advances in Diagnosis and Treatment of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation
10.19746/j.cnki.issn1009-2137.2025.01.045
- VernacularTitle:造血干细胞移植后弥漫性肺泡出血诊治的最新研究进展
- Author:
Zhi-Bin XIE
1
;
Jia-Jia LI
1
Author Information
1. 蚌埠医科大学第一附属医院血液科,安徽 蚌埠 233003
- Publication Type:Journal Article
- Keywords:
hematopoietic stem cell transplantation;
diffuse alveolar hemorrhage;
diagnosis;
treatment
- From:
Journal of Experimental Hematology
2025;33(1):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse alveolar hemorrhage(DAH)is a severe complication that can occur post-hematopoietic stem cell transplantation(HSCT).So far,the precise pathogenesis and risk factors of DAH post-HSCT remain elusive,diagnostic criteria have not reached a consensus,and the efficacy of existing therapeutic measures is far from satisfactory.At present,it is believed that the core mechanism of DAH post-HSCT is a vicious cycle initiated by endothelial injury,accompanied by a series of subsequent inflammatory and cellular responses.Treatment primarily focuses on managing inflammation,promoting hemostasis,and improving oxygenation.This paper reviews recent advances in understanding the pathogenesis,risk factors,clinical manifestations,diagnosis,and treatment of DAH following HSCT.
