Recent Advances in Diagnosis and Treatment of Diffuse Alveolar Hemorrhage after Hematopoietic Stem Cell Transplantation --Review.
10.19746/j.cnki.issn.1009-2137.2025.01.045
- Author:
Zhi-Bin XIE
1
;
Jia-Jia LI
1
Author Information
1. Department of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233003, Anhui Province, China.
- Publication Type:English Abstract
- Keywords:
hematopoietic stem cell transplantation;
diffuse alveolar hemorrhage;
diagnosis;
treatment
- MeSH:
Humans;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Hemorrhage/etiology*;
Pulmonary Alveoli;
Lung Diseases/etiology*;
Risk Factors
- From:
Journal of Experimental Hematology
2025;33(1):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Diffuse alveolar hemorrhage (DAH) is a severe complication that can occur post- hematopoietic stem cell transplantation (HSCT). So far, the precise pathogenesis and risk factors of DAH post-HSCT remain elusive, diagnostic criteria have not reached a consensus, and the efficacy of existing therapeutic measures is far from satisfactory. At present, it is believed that the core mechanism of DAH post-HSCT is a vicious cycle initiated by endothelial injury, accompanied by a series of subsequent inflammatory and cellular responses. Treatment primarily focuses on managing inflammation, promoting hemostasis, and improving oxygenation. This paper reviews recent advances in understanding the pathogenesis, risk factors, clinical manifestations, diagnosis, and treatment of DAH following HSCT.
