Advances in Study of Erythroblastic Island Macrophages--Review.
10.19746/j.cnki.issn.1009-2137.2025.01.044
- Author:
Zhao-Hui WANG
1
;
Shuang DING
2
Author Information
1. School of Medical Technology, Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
2. Department of Laboratory Medicine, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.
- Publication Type:English Abstract
- Keywords:
erythroblastic island macrophages;
bone marrow microenvironment;
erythropoiesis;
cell model
- MeSH:
Macrophages/cytology*;
Humans;
Erythroblasts/cytology*;
Animals;
Hematopoietic Stem Cells/cytology*
- From:
Journal of Experimental Hematology
2025;33(1):292-295
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow microenvironment is the environment in which hematopoietic stem cells live, mainly composed of bone marrow stromal cells, microvessels, nerves, and cytokines secreted by stromal cells. The bone marrow microenvironment plays a crucial role in the self-renewal, directed differentiation and proliferation of hematopoietic stem cells and the regulation of proliferation, differentiation and maturation of hematopoietic cells. A class of macrophages exists in the bone marrow microenvironment, the bone marrow-resident tissue macrophages, which plays a crucial role in maintaining homeostasis in vivo, and three subpopulations of bone marrow-resident tissue macrophages have been characterized: erythroblastic island macrophages (EIMs), hematopoietic stem cell niche macrophages, and bone macrophages. This review focuses on the functions, surface markers and modeling of EIMs.
