Predictive Value of Platelet Parameters for Arterial Complications in Patients with Myeloproliferative Neoplasms.
10.19746/j.cnki.issn.1009-2137.2025.01.029
- Author:
Sen ZHAO
1
;
Ye CHEN
1
;
Xiu-Wen REN
2
Author Information
1. Department of Hematology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
2. School of Public Health, Capital Medical University, Beijing 100069, China.
- Publication Type:Journal Article
- Keywords:
polycythemia vera;
essential thrombocythemia;
arterial events;
ischemic stroke;
platelet parameters
- MeSH:
Humans;
Middle Aged;
Female;
Male;
Aged;
Retrospective Studies;
Adult;
Thrombocythemia, Essential/blood*;
Myeloproliferative Disorders/complications*;
Aged, 80 and over;
Polycythemia Vera/blood*;
Blood Platelets;
Platelet Count;
Young Adult;
Mean Platelet Volume
- From:
Journal of Experimental Hematology
2025;33(1):198-205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the occurrence of arterial events and platelet parameters in patients with polycythemia vera (PV) and essential thrombocythemia (ET), and to explore the characteristics of platelet parameters in patients with PV and ET and their relationship with arterial complications.
METHODS:The clinical and laboratory data of newly diagnosed PV and ET patients who visited the Department of Hematology, Beijing Anzhen Hospital, Capital Medical University from August 2017 to August 2022 were retrospectively analyzed.
RESULTS:86 MPN patients (46 males and 40 females) were enrolled, including 44 PV patients and 42 ET patients, with an median age of 61(23-83) years. The mutation rate of JAK2V617F gene, the number of megakaryocytes in bone marrow, the incidence of splenomegaly, and the levels of white blood cell count (WBC), hemoglobin (HGB), hematocrit (HCT), platelet distribution width (PDW), mean platelet volume (MPV), platelet-large cell ratio (P-LCR) in PV patients were significantly higher than those in ET patients (P < 0.05), while the levels of PLT and PCT were significantly lower than those in ET patients (P < 0.01). 22 cases (50%) of PV patients were complicated with arterial events, of which 12 had arterial stenosis in≥2 locations. Among arterial events, the PDW of PV patients with ischemic stroke was greater than that of PV patients without ischemic stroke (P =0.003), and the PDW of PV patients with arterial stenosis in≥2 locations was greater than that of PV patients with arterial stenosis in≤1 location (P =0.037). 23 cases (54.8%) of ET patients were complicated with arterial events, and 7 cases had arterial stenosis in≥2 locations. In arterial events, the PCT of ET patients complicated with ischemic stroke was greater than that of ET patients without ischemic stroke (P =0.037), and the PCT of ET patients with≥2 locations of arterial stenosis was greater than that of ET patients with≤1 location of arterial stenosis (P =0.049). The binary logistic regression analysis showed that elevated PDW and PCT were risk factors for ischemic stroke in PV and ET patients, respectively (P < 0.05).
CONCLUSION:The platelet parameters of PV and ET patients exhibit significantly different characteristics. Elevated PDW and PCT can predict a higher risk of ischemic stroke in PV and ET patients, respectively.
