Effect and Safety of a New Conditioning Regimen with Chidamide and BEAM for Autologous Hematopoietic Stem Cell Transplantation in Lymphoma
10.19746/j.cnki.issn1009-2137.2025.01.017
- VernacularTitle:西达本胺联合BEAM预处理方案在自体造血干细胞移植淋巴瘤患者中的疗效及安全性分析
- Author:
Sen LI
1
;
Jin-Jie GAO
1
;
Yan LI
1
;
Fei DONG
1
;
Qi-Hui LI
1
;
Wei ZHAO
1
;
Wei WAN
1
;
Ping YANG
1
;
Ji-Jun WANG
1
;
Hong-Mei JING
1
Author Information
1. 北京大学第三医院血液科,北京 100191
- Publication Type:Journal Article
- Keywords:
lymphoma;
conditioning regimen;
autologous hematopoietic stem cell transplantation;
chidamide
- From:
Journal of Experimental Hematology
2025;33(1):121-126
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the efficacy and safety of a new conditioning regimen with chidamide and BEAM for autologous hematopoietic stem cell transplantation(AHSCT)in patients with lymphoma.Methods:Medical records and further follow-up data from 85 patients with lymphoma from May 2015 to September 2020 in our hospital were retrospectively collected and analyzed.Results:Among 85 patients,52 cases accepted BEAM regimen and 33 cases accepted CBEAM followed by AHSCT.In CBEAM group,18 patients(54.5％)received AHSCT as salvage therapy,while only 26.9％(14 cases)for salvage in BEAM group(P＜0.01).CBEAM conditioning resulted in shorter neutrophil engraftment of 2 days,while no significant difference was found in platelet engraftment.Although the incidence of liver impairment was higher in CBEAM group(12.1％),the grade of impairment was only Ⅰ to Ⅱ.The two conditioning regimens both achieved good complete remission rate of over 90％,and no transplant-related death occurred.The median follow-up time in the CBEAM group was 18(12,22)months,and 39(20,59)months in the BEAM group.There were no significantly differences in 2-year progression-free survival(PFS)and overall survival(OS)rate between the two groups(P＞0.05).In patients with refractory or relapsed non-Hodgkin lymphoma,the 2-year PFS rate after transplantation in BEAM group and CBEAM group was 74.1％and 92.9％,respectively(P＞0.05),indicating that chidamide may have certain advantages in prolonging PFS.Conclusion:CBEAM conditioning regimen has a good efficacy and safety in lymphoma patients before AHSCT,especially in refractory and relapsed non-Hodgkin lymphoma patients,suggesting that it could serve as an alternative conditioning regimen prior to AHSCT for lymphoma.
