Clinical Characteristics and Prognosis Analysis of Patients with Extranasal NK/T-Cell Lymphoma: A Multicenter Retrospective Study of Huaihai Lymphoma Working Group.
10.19746/j.cnki.issn.1009-2137.2025.01.013
- Author:
Hui-Rong SHAN
1
;
Qing ZHANG
2
;
Ling WANG
3
;
Yu-Ye SHI
4
;
Yu-Qing MIAO
5
;
Tai-Gang ZHU
6
;
Jing-Jing YE
7
;
Xu-Dong ZHANG
8
;
Liang WANG
9
;
Zi-Yuan SHEN
2
;
Wei SANG
2
Author Information
1. Department of Hematology, Shuyang Hospital of Traditional Chinese Medicine, Suqian 223800, Jiangsu Province, China.
2. Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, Jiangsu Province, China.
3. Department of Hematology, Taian City Central Hospital, Taian 271000, Shandong Province, China.
4. Department of Hematology, Huai'an First People's Hospital, Huai'an 223000, Jiangsu Province, China.
5. Department of Hematology, Yancheng First People's Hospital, Yancheng 224001, Jiangsu Province, China.
6. Department of Hematology, The General Hospital of Wanbei CoalElectric Group, Suzhou 234011, Anhui Province, China.
7. Department of Hematology, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China.
8. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
9. Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China.
- Publication Type:English Abstract
- Keywords:
NK/T-cell lymphoma;
extranasal;
clinicopathological characteristics
- MeSH:
Adult;
Aged;
Female;
Humans;
Male;
Middle Aged;
Asparaginase/therapeutic use*;
Lymphoma, Extranodal NK-T-Cell/pathology*;
Prognosis;
Retrospective Studies;
Survival Rate;
Polyethylene Glycols
- From:
Journal of Experimental Hematology
2025;33(1):93-100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the clinical characteristics and prognostic factors of patients with extranasal NK/T-cell lymphoma (NKTCL).
METHODS:The clinical data of 138 patients with NKTCL diagnosed in 10 medical centers of Huaihai Lymphoma Working Group from June 2015 to April 2021 were collected and analyzed retrospectively. The differences in clinicopathological characteristics of patients with different involvement and efficacy of pegaspargase regimen were compared, as well as perform survival analysis.
RESULTS:A total of 138 extranasal NKTCL patients were included, with a median age of 46 years, and the ratio of males to females was approximately 2∶1. There were 39 patients with gastrointestinal involvement, 32 patients with oropharyngeal involvement, 17 patients with skin involvement, 11 patients with lymph node involvement, 11 patients with orbital involvement, and 28 patients with other parts involvement. Patients with skin involvement had a higher proportion of advanced disease and a lower proportion of CD56 positive rate compared to those with oropharyngeal involvement. Among the patients with gastrointestinal involvement, the survival rate of patients who received pegaspargase regimen was significantly higher than those who were treated without pegaspargase (P < 0.01). Multivariate analysis showed that serum creatinine was an independent prognostic factor for patients with skin involvement ( HR =1.027, 95%CI : 1.001-1.054, P =0.040), ECOG PS and EBV DNA were independent prognostic factors for patients with gastrointestinal involvement ( HR =2.635, 95%CI : 1.096-6.338, P =0.030; HR =4.772, 95% CI : 1.092-20.854, P =0.038), and ECOG PS and CA stage were independent prognostic factors for patients with oropharyngeal involvement ( HR =13.875, 95%CI : 2.517-76.496, P =0.002; HR =20.261, 95%CI : 2.466-166.470, P =0.005).
CONCLUSION:The clinicopathological characteristics of extranasal NKTCL patients with different sites of involvement are vary, and effective individualized treatment need to be further explored.
