Primary hepatic neuroendocrine neoplasms: a case series analysis of 10 patients and literature review.
10.3724/zdxbyxb-2025-0488
- Author:
Yin JIANG
1
,
2
;
Yudi MENG
3
;
Shiwei ZHANG
3
;
Yongtao WANG
4
;
Chunnian WANG
5
;
Caide LU
6
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo 315040, Zhejiang Province, China. cdduanshui@
2. com.
3. Health Science Center, Ningbo University, Ningbo 315211, Zhejiang Province, China.
4. Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo 315040, Zhejiang Province, China.
5. Ningbo Clinical Pathology Diagnosis Center, Ningbo 315021, Zhejiang Province, China.
6. Department of Hepatobiliary and Pancreatic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo 315040, Zhejiang Province, China. lucaide@nbu.edu.cn.
- Publication Type:English Abstract
- Keywords:
Hepatectomy;
Neuroendocrine neoplasms;
Primary hepatic neuroendocrine neoplasms;
Retrospective study
- MeSH:
Humans;
Middle Aged;
Male;
Female;
Neuroendocrine Tumors/pathology*;
Liver Neoplasms/pathology*;
Retrospective Studies;
Aged;
Adult
- From:
Journal of Zhejiang University. Medical sciences
2025;54(5):661-667
- CountryChina
- Language:Chinese
-
Abstract:
The clinical data of 10 patients with pathologically confirmed primary hepatic neuroendocrine neoplasms (PHNENs) were retrospectively analyzed. The cohort included 8 males and 2 females, with a median age of 63 years. None presented with carcinoid syndrome. Three cases were detected incidentally during health check-ups, 2 presented with painless jaundice, and 5 reported abdominal distension or pain (1 with concurrent jaundice). Elevated tumor markers included carbohydrate antigen 19-9 in 4 cases, alpha-fetoprotein in 2 cases, and neuron-specific enolase in 1 case. All patients underwent surgical resection, including hepatectomy and hilar cholangiocarcinoma resection, combining with resection and reconstruction of right hepatic artery, resection of liver metastases and pancreaticoduodenectomy according to the extent of tumor invasion.Preoperative imaging failed to diagnose neuroendocrine neoplasms in all cases. Final pathological diagnoses were neuroendocrine tumor (NET) G2 in 5 cases, NET G3 in 1 case, and neuroendocrine carcinoma (NEC) in 4 cases. During the follow-up, 4 patients died and 6 survived. The study demonstrates that PHNENs lack specific clinical or imaging features, and the diagnosis relies on pathological examination after excluding metastatic disease. Radical resection remains the primary treatment, with prognosis varying significantly by tumor grade.
