Clinical efficacy of human biological dressing transplantation for refractory wounds in middle-aged and elderly patients.
10.3724/zdxbyxb-2025-0204
- Author:
Xiangwei LING
1
;
Peng ZHANG
2
;
Tingting ZHANG
2
;
Su LI
3
Author Information
1. Department of Wound Healing, the First Affiliated Hospital of Wenzhou Medical University, National Key Clinical Specialty, Wenzhou 325000, Zhejiang Province, China. 330166364@qq.com.
2. Burn Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.
3. Burn Department, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China. 1131849083@qq.com.
- Publication Type:English Abstract
- Keywords:
Autologous skin grafting;
Efficacy;
Human biological dressing;
Middle-aged and elderly patients;
Refractory wound;
Retrospective study
- MeSH:
Humans;
Aged;
Male;
Middle Aged;
Female;
Aged, 80 and over;
Retrospective Studies;
Wound Healing;
Biological Dressings;
Skin Transplantation;
Acellular Dermis;
Wounds and Injuries/surgery*;
Treatment Outcome
- From:
Journal of Zhejiang University. Medical sciences
2025;54(5):620-627
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To evaluate the clinical efficacy of human biological dressing (human acellular dermal matrix) transplantation in the management of refractory wounds among middle-aged and elderly patients.
METHODS:A retrospective observational study was conducted involving 104 middle-aged and elderly patients (74 males, 30 females; aged 56-95 years) with refractory wounds treated at the First Affiliated Hospital of Wenzhou Medical University from January 2023 to December 2024. Following debridement, wound areas ranged from 1.0 to 48.0 cm². All patients received vacuum sealing drainage for 7 days, followed by human biological dressing transplantation. Subsequently, depending on the wound condition and the patient's preference, autologous skin grafting (ASG) or wound dressing changes were employed to promote wound healing. Outcome measures included: post-human biological dressing coverage of exposed tendons/bones and occurrence of tendon infection/osteomyelitis; survival rate of ASG at postoperative day 7; healing time in patients managed with wound dressing changes alone; patient satisfaction; and changes in pain intensity, sleep disturbance, and anxiety scores assessed before and 1 month after human biological dressing transplantation using the Edmonton Symptom Assessment Scale.
RESULTS:After human biological dressing transplantation, 103 patients exhibited robust granulation tissue formation achieving complete coverage of the exposed tendons/bones, with no instances of tendon/bone necrosis, infection, or osteomyelitis. Among these, 51 patients underwent successful ASG at (44.4±13.0) d post-human biological dressing transplantation (success rate 100.00%), 52 patients achieved primary wound healing through dressing changes alone within (62.6±13.4) d post-human biological dressing transplantation. One patient experienced human biological dressing dissolution and detachment due to gluteal wound infection, resulting in non-healing. The overall cure rate was 99.04%. Patient satisfaction survey showed that 95 patients were very satisfied, 8 were satisfied, and 1 was dissatisfied (satisfaction rate 99.04%). Pain, sleep disturbance, and anxiety scores at 1 month post-human biological dressing transplantation were significantly reduced compared to pre-transplantation scores (all P<0.05).
CONCLUSIONS:Human biological dressing transplantation demonstrate excellent outcomes in treating refractory wounds in middle-aged and elderly patients and can serve as an effective therapeutic strategy for managing refractory wounds.
